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ISOLIQUIRITIGENIN
SynDRA canonical compound SYN0004536 — structure-anchored drug synonym record
| Clinical phase | Preclinical |
|---|
| Primary target(s) | AKR1B1 | GABBR1 | HRH2 | SIRT1 |
|---|
| Mechanism of action | guanylate cyclase activator |
|---|
All known targets
Mechanisms of action (all sources)
- guanylate cyclase activator
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- MMP9
- CYP19A1
- ESR1
- P4HB
- NLRP3
- DAPK1
- PSMB5
- MMP7
- ESR2
- HSD17B1
- HSD17B2
- MMP3
- MMP2
- MMP13
- MMP1
- PIN1
- MPHOSPH8
- MTOR
- NFE2L2
- NPSR1
- MET
- APEX1
- PMP22
- LMNA
- POLI
- POLK
- PPARG
- PTPN1
- RELA
- SLCO1B3
- SMAD3
- SMARCA2
- SNCA
- SRC
- TDP1
- TP53
- TYR
- USP1
- MAPT
- KCNH2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ADCY9
- AHR
- CP2CJ
- CP3A4
- GEMI
- GLSK
- IDHC
- KSYK
- NPR1
- NSD2
- NTM1A
- SMCA2
- SYK
- UBP1
Drug classes
Cross-references
Synonyms
- 6'-deoxychalcone
- trihydroxychalcone
- 2',4',4-Trihydroxychalcone
- Chalcone, 2',4,4'-trihydroxy-
- GU-17
- B9CTI9GB8F
- trans-2',4,4'-trihydroxychalcone
- (E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-propenone
- CHEBI:310312
- RefChem:51351
- DTXCID202466
- 2',4,4'-Trihydroxychalcone
- 4,2',4'-Trihydroxychalcone
- MFCD00075907
- Isoliquiritigen
- 1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one
- Acrylophenone, 2',4'-dihydroxy-3-(p-hydroxyphenyl)-
- 2-PROPEN-1-ONE, 1-(2,4-DIHYDROXYPHENYL)-3-(4-HYDROXYPHENYL)-
- SMR000112969
- CCRIS 7676
- SR-01000075499
- EINECS 237-316-5
- UNII-B9CTI9GB8F
- BRN 1914295
- ILTG
- ISLQ
- Isoliquiritigenin, powder
- Spectrum5_000612
- Isoliquiritigenin, natural
- Isoliquiritigenin (Standard)
- Lopac0_000681
- BSPBio_003411
- 1-08-00-00707 (Beilstein Handbook Reference)
- MLS000438943
- MLS002207240
- MLS006010045
- 4,2?,4?-Trihydroxychalcone
- BIDD:ER0235
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