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THIOTHIXENE
SynDRA canonical compound SYN0004526 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | DRD1 | DRD2 | HRH1 | HTR2A |
|---|
| Mechanism of action | dopamine receptor antagonist |
|---|
| Indication | schizophrenia |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- DRD2
- HTR2A
- HRH1
- DRD1
- ADRA1A
- HTR7
- HTR6
- HTR5A
- HTR3A
- HTR2C
- HTR1D
- HTR1B
Mechanisms of action (all sources)
- DRD2 ANTAGONIST
- Dopamine D2 receptor antagonist
- HTR2A ANTAGONIST
- Serotonin 2a (5-HT2a) receptor antagonist
- dopamine receptor antagonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PDE4D
- SLC6A3
- KCNH2
- HTR2B
- TACR1
- NR1I2
- OPRD1
- NTSR1
- NR3C1
- NPY2R
- NPY1R
- MPHOSPH8
- NPSR1
- OPRM1
- MLNR
- MC4R
- MC3R
- MAOA
- OPRK1
- ABCB11
- PDE3A
- SLCO1B3
- UBE2N
- TRPV1
- TDP1
- TBXA2R
- TARDBP
- SMAD3
- SLCO1B1
- KDM4E
- SLC6A2
- SLC29A1
- PTGS2
- POLK
- POLI
- PGR
- KMT2A
- KDM4A
- ADORA1
- ATXN2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Dopamine Agents
- Dopamine Antagonists
- Neurotransmitter Agents
- Psychotropic Drugs
- Tranquilizing Agents
- Typical Antipsychotic
ATC classes
Cross-references
Synonyms
- NAVANE
- THIOTHIXENE HYDROCHLORIDE
- THIOTHIXENE HYDROCHLORIDE INTENSOL
- tiotixene
- cis-Thiothixene
- thiothixene hydrochloride
- thiothixene HCl
- Tiotixene
- Tiotixeno
- Thiothixene cis-isomer
- (z)-thiothixene
- Cis-thiothixene
- CP-12252-1
- NSC-108165
- P-4657 B
- P-4657B
- Navane
- Orbinamon
- Navan
- Navaron
- Thiothixine
- Tiotixenum
- Thiothixene hydrochloride
- CP 12252-1
- Cis-Thiothixene
- Navane (TN)
- P-4657-B
- P-4657A
- Thiothixene (USP)
- Thiothixene (Z)
- Thiothixene Hydrochloride (base)
- Thiothixene [USAN:BAN]
- Tiotixene (JAN)
- Tiotixeno [INN-Spanish]
- Tiotixenum [INN-Latin]
- Trans-Thiothixene
- CP-12,252-1
Reported adverse events
- Dry mouth
- Dyskinesia
- Dystonia
- Hyperreflexia
- Rash
- Restlessness
- Seizure
- Sudden death
- Tachycardia
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