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PRUCALOPRIDE
SynDRA canonical compound SYN0004249 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | HTR4 |
|---|
| Mechanism of action | serotonin receptor agonist |
|---|
| Indication | constipation |
|---|
| Disease area | gastroenterology |
|---|
All known targets
Mechanisms of action (all sources)
- HTR4 AGONIST
- Serotonin 4 (5-HT4) receptor agonist
- HTR4 PARTIAL AGONIST
- serotonin receptor agonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR1A
- KCNH2
- ACHE
- MLNR
- NR1I2
- NEIL2
- NEIL1
- MUTYH
- MPG
- MAOA
- MC3R
- HDAC6
- HTR2C
- HTR2B
- HTR2A
- HRH3
- NR3C1
- OGG1
- OPRD1
- OPRM1
- PDE3A
- PDE4A
- PDE4D
- PGR
- PPARG
- PTGS1
- PTGS2
- S1PR1
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- TBXA2R
- HRH1
- GPR35
- ADGRF1
- ADRB1
- C5AR1
- AVPR1A
- AR
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Gastrointestinal Agents
- Laxatives
- Neurotransmitter Agents
- Serotonin 5-HT4 Receptor Agonists
- Serotonin Agents
- Serotonin Receptor Agonists
- Serotonin 4 Receptor Agonists
- Serotonin-4 Receptor Agonist
ATC classes
- A06A · DRUGS FOR CONSTIPATION
Cross-references
Synonyms
- MOTEGRITY
- Motegrity
- PRUCALOPRIDE SUCCINATE
- motegrity
- prucalopride succinate
- resolor
- R093877
- Prucaloprida
- R-093877
- Resolor
- R0-93877
- UNII-0A09IUW5TP
- 0A09IUW5TP
- C18H26ClN3O3
- CHEMBL117287
- R 093877
- Prucalopride [USAN:INN:BAN]
- KB-6806
- Prucalopride succinate
- Prucalopride Succinat
- Prucalopride (succinate)
- UNII-4V2G75E1CK
- R 108512
- Prucalopride succinate [USAN]
- 4V2G75E1CK
- AK175654
- Prucalopride succinate (USAN)
- resotran
- resotrans
- DTXCID2031459
- prucalopridum
- RefChem:57530
- A06AX05
- MFCD09837787
- Prucalopride?
- Prucalopride Impurity V
- Prucalopride (Standard)
- PRUCALOPRIDE [MI]
Reported adverse events
- Dizziness
- Fatigue
- Headache
- Nausea
- Vomiting
- Completed suicide
- Flatulence
- Hypersensitivity
- Pollakiuria
- Abdominal distension
- Abdominal pain
- Decreased appetite
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