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TORSEMIDE
SynDRA canonical compound SYN0004098 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SLC12A1 |
|---|
| Mechanism of action | Electrolyte reabsorption inhibitor |
|---|
| Indication | congestive heart failure | edema | hypertension |
|---|
| Disease area | cardiology |
|---|
All known targets
Mechanisms of action (all sources)
- Thromboxane receptor antagonist
- Electrolyte reabsorption inhibitor
- SLC12A1 INHIBITOR
- Sodium-(potassium)-chloride cotransporter 2 inhibitor
- SLC12A1 BLOCKER
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABL1
- NPY2R
- MMP9
- MMP1
- MLNR
- MDH1
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- KDM4E
- KCNH2
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH2
- HRH1
- HMGCR
- HIF1A
- HDAC6
- GSK3B
- GHSR
- NPY1R
- NR1I2
- FLT1
- NR3C1
- TRIM24
- TBXAS1
- TBXA2R
- TARDBP
- TACR2
- TACR1
- SLCO1B3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Loop Diuretic
- Antihypertensive Agents
- Cardiovascular Agents
- Diuretics
- Membrane Transport Modulators
- Natriuretic Agents
- Sodium Potassium Chloride Symporter Inhibitors
ATC classes
- C03C · HIGH-CEILING DIURETICS
Cross-references
Synonyms
- DEMADEX
- SOAANZ
- Soaanz
- Upcard
- torasemide
- toradiur
- Torasemide
- Torasemide anhydrous
- Torasemida
- Luprac
- AC-4464
- AC4464
- BM-02.015
- BM-02015
- BM02.015
- Demadex
- Isemid
- Torem 10
- Torem 2.5
- Torem 5
- Dilutol
- Presoril
- Sutril
- Toradiur
- Torasemidum
- Torem
- Torocard
- Torrem
- Unat
- Torasemide N
- Torsemide [USAN]
- AC 4464
- JDL-464
- Demadex (TN)
- Demadex, Torsemide
- GJ-1090
- KS-1123
Reported adverse events
- Pancreatitis
- Stevens-Johnson syndrome
- Hypotension
- Ototoxicity
- Arthralgia
- Headache
- Hypersensitivity
- Angioedema
- Asthenia
- Constipation
- Cough
- Dizziness
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