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SB-216763
SynDRA canonical compound SYN0003956 — structure-anchored drug synonym record
| Clinical phase | Preclinical |
|---|
| Primary target(s) | GSK3B |
|---|
| Mechanism of action | GSK-3 inhibitor |
|---|
All known targets
Mechanisms of action (all sources)
- GSK-3 inhibitor
- GSK3A INHIBITOR
- GSK3B INHIBITOR
- glycogen synthase kinase inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- SRPK1
- MAPK15
- CDK1
- PIM3
- HIPK3
- STK3
- RPS6KA1
- DYRK1A
- HIPK2
- PAX8
- PKN2
- PIN1
- PLK1
- PIM2
- PIM1
- POLB
- PDPK1
- AKT1
- PAK5
- PAK6
- POLI
- PAK4
- NFKB1
- NEK7
- NEK6
- NEK2
- MYLK
- MPHOSPH8
- MKNK2
- MKNK1
- MELK
- POLH
- PRKCA
- POLK
- RPS6KA3
- USP1
- TSG101
- TP53
- THPO
- TDP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ABC3F
- ABC3G
- UBP1
- TRFR
- TNNT2
- TNNI3
- TNNC1
- PE2R2
- OXYR
- NSD2
- IDE
- HXA9
- HCRTR1
- GP183
- FXN
- ESRRA
- CRHR2
- CRHBP
- CP3A4
- CP2CJ
- CP2C9
- CP1A2
- CCNB3
- CCNB2
- CCNB1
- CCNA1
- B2CL1
- V1AR
Cross-references
Synonyms
- SB 216763
- SB216763
- 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
- 3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione
- 1H-Pyrrole-2,5-dione, 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-
- CHEMBL102714
- 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
- SR-01000076052
- Tocris-1616
- Lopac-S-3442
- AC1L41YI
- Lopac0_000934
- SCHEMBL30251
- MLS001074894
- cid_176158
- BDBM8296
- GTPL8015
- CTK8B4807
- CHEBI:91421
- AOB5004
- SYN1075
- EX-A291
- RefChem:884636
- MFCD09753369
- C19H12Cl2N2O2
- JCSGFHVFHSKIJH-UHFFFAOYSA-N
- orb1304564
- SCHEMBL29358424
- SCHEMBL29361308
- GLXC-06773
- HMS2235H21
- HMS3244K13
- HMS3244K14
- HMS3244L13
- HMS3262L10
- HMS3268I05
- HMS3295K21
- HMS3373J13
- HMS3412N05
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