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ACITRETIN
SynDRA canonical compound SYN0003952 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | RARA | RARB | RARG | RBP1 | RXRA | RXRB | RXRG | STAT3 |
|---|
| Mechanism of action | retinoid receptor agonist |
|---|
| Indication | psoriasis |
|---|
| Disease area | dermatology |
|---|
All known targets
- RARA
- RARG
- RARB
- RXRA
- RXRB
- RXRG
- STAT3
- ABCB11
- Abcb11
- RBP1
Mechanisms of action (all sources)
- RXRB AGONIST
- Retinoid receptor agonist
- RARG AGONIST
- RXRG AGONIST
- RARB AGONIST
- RARA AGONIST
- RXRA AGONIST
- STAT3 INHIBITOR
- protein synthesis inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NR1I2
- ESR1
- ABCC2
- HTR2B
- OPRK1
- OPRD1
- NR3C1
- NPY1R
- MLNR
- MC4R
- MC3R
- MAPT
- MAOA
- KDM4A
- KCNH2
- KAT2A
- HTR3A
- OPRM1
- PDE3A
- PDE4D
- SLC6A2
- USP1
- TDP1
- TBXA2R
- SMN1
- SLC6A4
- SLC6A3
- SLC29A1
- PGR
- SAMHD1
- RAPGEF4
- RAPGEF3
- PTGS2
- POLH
- PLK1
- HTR2C
- HTR2A
- ABCC4
- ADRB1
- BDKRB2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP19A
- GEMI
- GPX4
- KCMB1
- KCMB2
- KCMB4
- KSYK
- LRC26
- NSD2
- NTM1A
- NTMT1
- PAFA
- RPGF4
- SYK
- TP53
- UBP1
Drug classes
- Retinoid
- Dermatologic Agents
- Keratolytic Agents
ATC classes
- D05B · ANTIPSORIATICS FOR SYSTEMIC USE
Cross-references
Synonyms
- SORIATANE
- acitretinoin
- etretin
- neotigason
- soriatane
- isoacitretin
- isoetretin
- Acitretine
- Acitretina
- Etretin
- RO 10-1670
- RO-10-1670/000
- RO-101670000
- Ro-10-1670-000
- Neotigason
- Soriatane
- Acitretinum
- Isoacitretin
- Isoetretin
- TMMP
- Acitretina [Spanish]
- Acitretine [French]
- Acitretinum [Latin]
- Retinoid etretin
- U0279
- Ro-10-1670
- Ro-13-7652
- Soriatane (TN)
- Soriatane, Acitretin
- Acitretin (USAN/INN)
- Acitretin [USAN:INN:BAN]
- All-trans-Acitretin
- Ro-10-1670/000
- 13-cis-Acitretin
- LCH760E9T7
- acitretin (usp impurity)
- acitretin (usp monograph)
Reported adverse events
- GI malformation
- Hepatotoxicity
- Dysphonia
- Arthralgia
- Cheilitis
- Dizziness
- Dry mouth
- Flushing
- Headache
- Jaundice
- Stomatitis
- Conjunctivitis
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