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DOXIFLURIDINE
SynDRA canonical compound SYN0003949 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | TYMS |
|---|
| Mechanism of action | Thymidylate synthase inhibitor |
|---|
| Indication | colorectal cancer |
|---|
| Disease area | oncology |
|---|
All known targets
- TYMS
- DPYD
- CD44
- Candi TMP1
- TERT
- ABCC5
- ABCC11
- CYP19A1
- Tyms
- upp
Mechanisms of action (all sources)
- thymidylate synthase inhibitor
- TYMS INHIBITOR
- DNA synthesis inhibitor
- RNA synthesis inhibitor
- Candi TMP1 INHIBITOR
- DPYD INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR1
- ACHE
- LMNA
- MPHOSPH8
- MMP9
- MMP1
- MC5R
- MC4R
- MC3R
- MAPT
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- NPY2R
- KDR
- KCNH2
- HTR6
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- NPY1R
- NR3C1
- HDAC6
- PTPRC
- UPP1
- TYMP
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SLC6A4
- SLC6A3
- SLC6A2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Antimetabolites
- Antimetabolites, Antineoplastic
- Antineoplastic Agents
- Appetite Stimulants
- Central Nervous System Agents
- Central Nervous System Stimulants
- Immunologic Factors
- Immunosuppressive Agents
- Noxae
- Nucleic Acid Synthesis Inhibitors
- Nucleoside Metabolic Inhibitor
ATC classes
Cross-references
Synonyms
- 5-DFUR
- flutron
- furtulon
- Doxifluridina
- 5'-deoxy-5-fluorouridine (5'-dfur)
- Flutron
- Fulturon
- Furtulon
- NSC-758890
- RO-219738
- Capecitabine related compound b
- Furtulon (TN)
- 5'-Deoxy-5-fluorouridine
- 5-fluoro-5'-deoxyuridine
- 5'-Dfur
- Uridine, 5'-deoxy-5-fluoro-
- Doxifluridinum
- Ro-21-9738
- 1-(beta-D-5-Desoxyribofuranoxyl)-5-fluoruracil
- CHEMBL1130
- V1JK16Y2JP
- 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione
- CHEBI:31521
- NSC 758890
- NCGC00093926-03
- 5'FDUR
- MFCD00866530
- 5'-Doxifluridine
- 5'-dFUrd
- 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-tetrahydrofuran-2-yl]-5-fluoro-pyrimidine-2,4-dione
- SMR000326811
- CAS-3094-09-5
- Uridine-5'-deoxy-5-fluoro-
- 5'dFUrd
- SR-01000075886
- Doxifluridine [INN:JAN]
- Doxifluridinum [INN-Latin]
- Doxifluridina [INN-Spanish]
Reported adverse events
- Death
- Arthralgia
- Asthenia
- Constipation
- Cough
- Dyspepsia
- Lethargy
- Nausea
- Pyrexia
- Rash
- Stomatitis
- Vomiting
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