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TRIFLURIDINE
SynDRA canonical compound SYN0003947 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | TYMS |
|---|
| Mechanism of action | DNA directed DNA polymerase inhibitor |
|---|
| Indication | virus herpes simplex (HSV) |
|---|
| Disease area | infectious disease |
|---|
All known targets
Mechanisms of action (all sources)
- thymidylate synthase inhibitor
- DNA directed DNA polymerase inhibitor
- Candi TMP1 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- DRD3
- ADORA1
- MLNR
- OPRD1
- NR3C1
- NR1I2
- NPY1R
- NFE2L2
- MC4R
- HTR2B
- MC3R
- MAOA
- LMNA
- KCNH2
- IDH1
- HTR3A
- OPRK1
- OPRM1
- PDE3A
- PDE4D
- PGR
- POLI
- PTGS2
- SAMHD1
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- SLCO1B1
- SLCO1B3
- SMN1
- TBXA2R
- TDP1
- HTR2C
- HTR2A
- ADORA2A
- HTR1A
- ADORA3
- ADRA1A
- ADRA2A
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- A4
- ATXN2
- TF65
- SYK
- NSD2
- NFKB1
- NF2L2
- NCOA3
- NCOA1
- MLP3A
- MDM4
- MDM2
- KSYK
- JAK2
- IFNG
- HXA9
- GLI3
- ESRRA
- ESR2
- BRCA1
- BARD1
- TP53
Drug classes
- Nucleic Acid Synthesis Inhibitors
- Nucleoside Analog Antiviral
- Nucleoside Metabolic Inhibitor
- Anti-Infective Agents
- Antimetabolites
- Antiviral Agents
- Noxae
ATC classes
- L01B · ANTIMETABOLITES
- S01A · ANTIINFECTIVES
Cross-references
Synonyms
- LONSURF
- Lonsurf
- TIPIRACIL HYDROCHLORIDE AND TRIFLURIDINE
- VIROPTIC
- trifluorothymidine
- 5-Trifluorothymidine
- Trifluridina
- F3dthd
- NSC-529182
- NSC-75520
- T.f.t.
- Trifluridine component of lonsurf
- Trifluridine component of s-95005
- Trifluridine component of tas-102
- Triherpine
- Viroptic
- Fluridine
- TFDU
- TRIFLUOROTHYMIDINE
- Trifluoridine
- Trifluoromethyldeoxyuridine
- Trifluridinum
- Virophta
- Trifluorothymine deoxyriboside
- CF3dUrd
- F3DThd
- F3T
- F3TDR
- HS-0007
- Trifluridina [INN-Spanish]
- Trifluridine [USAN:INN]
- Trifluridinum [INN-Latin]
- Viroptic (TN)
- Trifluridine (USP/INN);Viroptic, Trifluorothymidine, Trifluridine
- Alpha,alpha,alpha-Trifluorothymidine
- 2'-Deoxy-5-(trifluoromethyl)uridine
- 2'-Deoxy-5-trifluoromethyluridine
Reported adverse events
- Abdominal pain
- Alopecia
- Constipation
- Dysgeusia
- Fatigue
- Headache
- Hypertension
- Infection
- Nausea
- Neutropenia
- Proteinuria
- Pyrexia
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