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HEXAMETHONIUM
SynDRA canonical compound SYN0003887 — structure-anchored drug synonym record
| Clinical phase | Preclinical |
|---|
| Primary target(s) | CHRNA2 | CHRNA3 | CHRNA4 | CHRNA6 |
|---|
| Mechanism of action | cholinergic receptor antagonist |
|---|
All known targets
- CHRNA4
- CHRNA6
- CHRNA2
- CHRNA3
- CHRNA1
- CHRNB1
- CHRNB2
- CHRNB4
- CHRNG
- Chrna4
- Chrnb2
- Malaria DHOdehase
Mechanisms of action (all sources)
- CHRNA2 MODULATOR
- CHRNA3 MODULATOR
- CHRNA4 MODULATOR
- CHRNA6 MODULATOR
- cholinergic receptor antagonist
- Malaria DHOdehase INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- APEX1
- MPHOSPH8
- TDP1
- SNCA
- SLCO1B3
- SLCO1B1
- SAMHD1
- RGS4
- RAB9A
- POLI
- PMP22
- NPSR1
- NFKB1
- LMNA
- ARSA
- IDH1
- HDAC6
- GMNN
- ERG
- EHMT2
- DRD1
- CYP3A4
- CYP2D6
- CYP2C9
- CYP2C19
- CYP1A2
- TSHR
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACHA2
- ACHA3
- ACHA4
- ACHA6
- RARA
- RXRA
Drug classes
- Antihypertensive Agents
- Cardiovascular Agents
- Cholinergic Agents
- Cholinergic Antagonists
- Ganglionic Blockers
- Neurotransmitter Agents
- Nicotinic Antagonists
- Peripheral Nervous System Agents
- Anti-Ulcer Agents
Cross-references
Synonyms
- benzohexamethonium
- hexamethone
- hexanium
- hexathonide
- hexamethonium bromide
- hexamethonium dibromide
- hexamethonium dibromide dihydrate
- Hexamethone
- Hexamethonium cation
- Hexamethonium ion
- Hexathonide
- 8-aminoquinolines
- Hexonium
- Benzohexamethonium
- Hexamethonum
- Bistrium
- Hexanium
- UNII-3C9PSP36Z2
- Esametonio [Italian]
- CHEMBL100622
- CHEBI:5700
- 3C9PSP36Z2
- N,N,N,N',N',N'-hexamethylhexane-1,6-diaminium
- NCGC00163239-01
- Hexane-1,6-bis(trimethylammonium)
- 1,6-Hexanediaminium, N,N,N,N',N',N'-hexamethyl-
- DSSTox_RID_80651
- DSSTox_CID_25053
- DSSTox_GSID_45053
- BRN 1760389
- Esametonio
- CHEMBL332524
- CAS-60-26-4
- Hexamethonium [INN]
- Ammonium, hexamethylenebis(trimethyl-
- trimethyl-[6-(trimethylazaniumyl)hexyl]azanium
- Bitartrate, Hexamethonium
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