← SynDRA

LY-294002

SynDRA canonical compound SYN0003814 — structure-anchored drug synonym record

All known targets

• PIK3CG
• PIK3CD
• PIK3CB
• PIK3CA
• MTOR
• PRKDC
• PLK1
• PDE2A
• RPS6KB1
• ROCK1
• PRKCA
• PIM1

Mechanisms of action (all sources)

• PLK inhibitor
• MTOR inhibitor
• Phosphodiesterase inhibitor
• DNA dependent protein kinase inhibitor
• BRD2 INHIBITOR
• BRD3 INHIBITOR
• BET bromodomain inhibitor
• PIK3CA INHIBITOR
• PIK3CB INHIBITOR
• PIK3CD INHIBITOR
• PIK3CG INHIBITOR
• PI3K inhibitor

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• PIK3R1
• CSNK2A2
• HTR2C
• STK33
• PIK3R2
• HTR2A
• PIM3
• PIK3C2B
• SYK
• CYP1A2
• PLK3
• PDE5A
• HIPK2
• PAK2
• PAK3
• PAK5
• PAK4
• ABL1
• OXSR1
• OPRM1
• PASK
• OPRK1
• OPRD1
• NUAK1
• NTRK2
• NTRK1
• NR3C1
• NPY2R
• PAK6
• PDGFRB
• PBK
• PIM2
• PPP3CA
• PMP22
• PLK4
• PLK2
• PKN2
• PKM
• PIK3C2G
• PDE3A

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• CP1A2
• CP2D6
• CSNK2A1
• CSNK2B
• GPR151
• KSYK
• NF2L2
• NSD2
• NTM1A
• NTMT1
• PIK3R5
• PK3CA
• PK3CB
• PK3CD
• PK3CG

Drug classes

• Enzyme Inhibitors

Cross-references

• PubChem CID: 3973
• ChEMBL: CHEMBL98350
• DrugBank: DB02656
• ChEBI: 65329
• KEGG: C15195
• PDB: LY2
• Wikipedia: LY294002
• TTD: D09SFV
• LINCS BRD: BRD-K27305650

Synonyms

• NSC-697286
• SF-1101
• LY294002
• 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
• 2-morpholino-8-phenyl-4H-chromen-4-one
• 2-morpholin-4-yl-8-phenyl-4H-chromen-4-one
• UNII-31M2U1DVID
• LY-294,002
• 2-(morpholin-4-yl)-8-phenyl-4H-chromen-4-one
• 31M2U1DVID
• 2-MORPHOLIN-4-YL-7-PHENYL-4H-CHROMEN-4-ONE
• CHEMBL98350
• 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl
• CHEBI:65329
• 2-morpholino-8-phenyl-chromen-4-one
• AK162301
• 2-(morpholin-4-yl)-8-phenylchromen-4-one
• LY2
• IN1266
• IN1268
• Lys 294002
• BMK1-D5
• H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-(9CI)
• 2-(4-Morpholino)-8-phenyl-4H-1-benzopyran-4-one
• 2-morpholin-4-yl-8-phenylchromen-4-one
• 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-(9CI)
• 8-Phenyl-2-(morpholin-4-yl)-chromen-4-one
• 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
• NSC 697286
• SF 1101
• RefChem:458194
• DTXCID4022650
• PI3K/BET INHIBITOR LY294002
• MFCD00270881
• 2-Morpholino-8-phenylchromone
• 4azt
• Kinome_3543
• Tocris-1130