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AMOXAPINE
SynDRA canonical compound SYN0003790 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SLC6A4 |
|---|
| Mechanism of action | Norepinephrine reputake inhibitor |
|---|
| Indication | depression |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- SLC6A2
- SLC6A4
- DRD2
- DRD4
- DRD3
- DRD1
- HTR6
- HTR2A
- DRD5
- HTR2B
- GABRB2
- HTR1A
Mechanisms of action (all sources)
- Norepinephrine reputake inhibitor
- SLC6A4 INHIBITOR
- Serotonin transporter inhibitor
- SLC6A2 INHIBITOR
- Norepinephrine transporter inhibitor
- DRD2 ANTAGONIST
- Dopamine receptor antagonist
- DRD3 ANTAGONIST
- DRD5 ANTAGONIST
- DRD4 ANTAGONIST
- DRD1 ANTAGONIST
- HTR6 ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- TACR1
- HRH2
- PDE4D
- OPRD1
- OPRK1
- ESR1
- ADRB2
- OPRM1
- HTR5A
- KCNH2
- MTOR
- NR3C1
- NPY2R
- NPY1R
- NPSR1
- NFKB1
- NFE2L2
- NTSR1
- ACHE
- MPHOSPH8
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- PDE3A
- PDE6A
- PDE5A
- TACR2
- VDR
- USP2
- USP1
- TSHR
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- 5HT6R
- SYK
- PRGR
- NPR2
- MDR1
- KSYK
- KCMB2
- KCMB1
- KCMA1
- JUN
- HTT
- GLI3
- GCR
- CP3A7
- CP3A4
- CP2D6
- CP2CJ
- CP2C9
- CP1A2
- CP19A
- ANDR
- ACM1
- TPO
Drug classes
- Adrenergic Agents
- Adrenergic Uptake Inhibitors
- Antidepressive Agents
- Antidepressive Agents, Tricyclic
- Central Nervous System Agents
- Dopamine Agents
- Dopamine Antagonists
- Membrane Transport Modulators
- Neurotransmitter Agents
- Neurotransmitter Uptake Inhibitors
- Psychotropic Drugs
- Selective Serotonin Reuptake Inhibitors
ATC classes
Cross-references
Synonyms
- ASENDIN
- amoxan
- moxadil
- desmethylloxapine
- Amoxapina
- CL-67,772
- CL-67772
- NSC-759559
- Asendin
- Asendis
- Defanyl
- Amoxan
- Amoxapinum
- Amoxepine
- Ascendin
- Demolox
- Desmethylloxapin
- Desmethylloxapine
- Moxadil
- A-129
- Amoxapina [INN-Spanish]
- Amoxapinum [INN-Latin]
- Asendin (TN)
- Asendis (TN)
- Defanyl (TN)
- Demolox (TN)
- KS-1197
- Moxadil (TN)
- Amoxapine (JP15/USP/INN)
- Amoxapine [USAN:BAN:INN:JAN]
- R63VQ857OT
- amoxapine (usp impurity)
- NSC 759559
- amoxapine (usp monograph)
- amoxapine (usp-rs)
- loxapine succinate impurity, amoxapine-(usp impurity)
- CHEBI:2675
Reported adverse events
- Neuroleptic malignant syndrome
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