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ARIPIPRAZOLE
SynDRA canonical compound SYN0003789 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HTR2C |
|---|
| Mechanism of action | Serotonin receptor antagonist |
|---|
| Indication | bipolar disorder | depression | schizophrenia |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- DRD2
- HTR2A
- HTR1A
- HRH1
- HTR2C
- HTR1D
- HTR1B
- HTR3A
- HTR1E
- ADRA1A
- HTR6
- DRD4
Mechanisms of action (all sources)
- Serotonin receptor agonist
- Serotonin receptor antagonist
- DRD2 PARTIAL AGONIST
- Dopamine D2 receptor partial agonist
- HTR1A PARTIAL AGONIST
- Serotonin 1a (5-HT1a) receptor partial agonist
- HTR2A ANTAGONIST
- Serotonin 2a (5-HT2a) receptor antagonist
- HTR1B FULL AGONIST
- HTR1D FULL AGONIST
- HTR2A PARTIAL AGONIST
- HTR2C PARTIAL AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HRH2
- MAOA
- TBXA2R
- TACR1
- ADORA3
- ADRB3
- AGTR1
- AR
- AVPR1A
- OPRM1
- PDE3A
- ESR1
- MLNR
- NR1I2
- NPY2R
- NR3C1
- MC4R
- NPY1R
- NPSR1
- NFE2L2
- OPRD1
- MC3R
- MAPT
- NTSR1
- PDE4D
- OPRK1
- PDE4A
- KDM4A
- PGR
- PPARG
- PTGS1
- PTGS2
- SAMHD1
- SCN5A
- SLC29A1
- SLC47A1
- SLC47A2
- TDP1
- KDR
- ABCB11
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT1B
- 5HT1D
- SYK
- RGS4
- PAFA
- MDM4
- MDM2
- M4K2
- M3K3
- KSYK
- HTR3E
- HTR3D
- HTR3C
- HTR3B
- GPR32
- GNA15
- GLI3
- ESRRA
- CP3A7
- CP2D6
- CP2C9
- APAF
- ANDR
- ADRA1D
- ACM1
- ACES
- 5HT2C
- TAAR1
Drug classes
- Atypical Antipsychotic
- Antidepressive Agents
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Dopamine Agents
- Dopamine Agonists
- Dopamine Antagonists
- Dopamine D2 Receptor Antagonists
- Neurotransmitter Agents
- Psychotropic Drugs
- Serotonin 5-HT1 Receptor Agonists
ATC classes
Cross-references
Synonyms
- ABILIFY
- ABILIFY ASIMTUFII
- ABILIFY MAINTENA KIT
- ABILIFY MYCITE KIT
- Abilify
- MEZOFY
- OPIPZA
- Opipza
- aripiprazole hydrate
- abilify
- arpizol
- pripiprazole
- OPC-14597
- Aripiprazol
- Abilify mycite
- Aripiprex
- NSC-759266
- OPC-31
- Abilify asimtufii
- Abilify maintena
- Abilify maintena kit
- Abilify mycite kit
- Aripiprazole accord
- Aripiprazole mylan pharma (previously aripiprazole pharmathen)
- Aripiprazole sandoz
- Aripiprazole zentiva
- Abilitat
- Abilify Discmelt
- Opc 14597
- Discmelt
- UNII-82VFR53I78
- C23H27Cl2N3O2
- HSDB 7320
- CHEMBL1112
- CHEBI:31236
- Aripiprazolum
- Aripirazole
Reported adverse events
- Fatigue
- Headache
- Akathisia
- Constipation
- Dystonia
- Somnolence
- Vomiting
- Nausea
- Anxiety
- Dysphagia
- Tremor
- Rash
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