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METITEPINE
SynDRA canonical compound SYN0003787 — structure-anchored drug synonym record
| Clinical phase | Preclinical |
|---|
| Primary target(s) | HTR7 |
|---|
| Mechanism of action | Anti-HCVE2 |
|---|
| Indication | antiviral |
|---|
| Disease area | Infectious disease |
|---|
All known targets
- HTR5A
- HTR6
- HTR7
- HTR1A
- HTR1B
- HTR1D
- HTR1E
- HTR1F
- HTR2A
- HTR2B
- HTR2C
Mechanisms of action (all sources)
- Anti-HCVE2
- HTR1A ANTAGONIST
- HTR1B INVERSE AGONIST
- HTR1D INVERSE AGONIST
- HTR1E ANTAGONIST
- HTR1F ANTAGONIST
- HTR2A ANTAGONIST
- HTR2B ANTAGONIST
- HTR2C INVERSE AGONIST
- HTR5A ANTAGONIST
- HTR6 ANTAGONIST
- HTR7 ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ALDH1A1
- APEX1
- MPHOSPH8
- MTOR
- NFE2L2
- NPC1
- NPSR1
- PIN1
- PMP22
- POLK
- PTCH1
- RAB9A
- RAD52
- RGS4
- SAMHD1
- SMAD3
- SMN1
- TDP1
- TP53
- UBE2N
- USP1
- MAPT
- MAPK1
- LMNA
- FEN1
- ATAD5
- ATXN2
- BAZ2B
- BCHE
- CBX1
- CYP3A4
- DRD1
- EHMT2
- GBA1
- KDM4A
- GLP1R
- GMNN
- HDAC6
- HTR3A
- HTR4
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT1A
- KSYK
- GAMT
- GEMI
- GLI3
- GNMT
- HNMT
- IDHC
- IFNG
- ITA4
- JUN
- M4K2
- DRD2
- MDM2
- MDM4
- NNMT
- NSD2
- PNMT
- PRGR
- RARA
- SMAD2
- STK33
- DRD3
- CP3A7
- 5HT1B
- ACM1
- 5HT1D
- 5HT1E
- 5HT1F
- 5HT2A
- 5HT2B
- 5HT2C
- 5HT5A
- 5HT6R
- 5HT7R
- ACM4
- CP3A4
- ACM5
- ADRB2
- ANDR
Drug classes
- Antipsychotic Agents
- Serotonin Antagonists
Cross-references
Synonyms
- Metitepina
- Methiotepin
- Methiothepine
- NSC-759875
- RO-8-6837
- METHIOTHEPIN
- Metitepinum
- Metitepine [INN]
- Metitepinum [INN-Latin]
- Metitepina [INN-Spanish]
- BRN 0626221
- (+-)-10-(4-Methylpiperazinyl)-8-(methylthio)-10,11-dihydrodibenzo(b,f)thiepin
- (+-)-8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin
- (+-)-1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine
- CHEBI:64203
- 1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine
- NCGC00024665-03
- DSSTox_CID_24000
- Methiothepin
- Ro 8-6837
- Maleate, Methiothepin
- NSC 759875
- DTXCID0024000
- RefChem:157019
- METHIOTHEPINMALEATE
- MLS000859918
- CAS-20229-30-5
- SMR000326779
- UNII-55D94103HL
- METITEPINE [MI]
- Prestwick0_000375
- Prestwick1_000375
- Prestwick2_000375
- Prestwick3_000375
- Spectrum2_001967
- Spectrum3_001602
- Spectrum4_001092
- Spectrum5_001832
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