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HYDROCORTISONE ACETATE
SynDRA canonical compound SYN0003669 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | NR3C1 |
|---|
| Mechanism of action | glucocorticoid receptor agonist |
|---|
| Indication | corticosteroid-responsive dermatoses |
|---|
| Disease area | dermatology |
|---|
All known targets
- NR3C1
- SERPINA6
- ANXA1
- NOS2
- NR3C2
- ESRRA
- ESRRB
- ESRRG
- KCNA1
- SHBG
- SLC47A1
- FNTA
Mechanisms of action (all sources)
- NR3C1 AGONIST
- Corticosteroid agonist
- NR3C1 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- AR
- PGR
- ACHE
- SAMHD1
- MAOA
- NFE2L2
- OPRM1
- PDE3A
- PDE4A
- PTGS1
- SLC6A2
- KDR
- SLC6A3
- SLC6A4
- SLCO1B1
- SLCO1B3
- TARDBP
- TBXA2R
- LMNA
- KCNH2
- ADORA3
- HTR2B
- ADRA1A
- ADRA2A
- APEX1
- ATAD5
- CHRM1
- CHRM2
- DRD1
- EHMT2
- ERG
- ESR1
- F2
- GMNN
- HIF1A
- HRH3
- HTR1A
- TDP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Corticosteroid Hormone Receptor Agonists
- Corticosteroid
- Anti-Inflammatory Agents
- Dermatologic Agents
ATC classes
- S01B · ANTIINFLAMMATORY AGENTS
- A07E · INTESTINAL ANTIINFLAMMATORY AGENTS
- S01C · ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
- D07A · CORTICOSTEROIDS, PLAIN
- D07X · CORTICOSTEROIDS, OTHER COMBINATIONS
- A01A · STOMATOLOGICAL PREPARATIONS
- R01A · DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
- C05A · AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
- H02A · CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
- S02B · CORTICOSTEROIDS
- CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
- CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Cross-references
Synonyms
- Anucort-HC
- BACITRACIN-NEOMYCIN-POLYMYXIN W/ HYDROCORTISONE ACETATE
- CARMOL HC
- CHLOROMYCETIN HYDROCORTISONE
- COLY-MYCIN S
- COR-OTICIN
- CORTEF ACETATE
- CORTIFOAM
- CORTISPORIN
- CORTRIL
- Caldecort
- Cortaid
- cortisol acetate
- hydroxycorticosterone acetate
- Hydrocortisone 21-acetate
- Cortisol 21-acetate
- Hydrocortisoni acetas
- NSC-741
- Barquinol hc
- Chloromycetin hydrocort
- Colifoam
- Cortef acetate
- Cortril
- Cortucid
- Dricort
- Framycort
- Fucidin h
- Genticin hc
- Gentisone hc
- Gppe ear susp
- Gppe eye crm
- Gppe foam aero
- Hc45 hydrocort
- Hemsol-hc
- Hepacort plus
- Hydrocal
- Hydrocortisone acetate component of carmol hc
- Hydrocortisone acetate component of chloromycetin hydrocortisone
Reported adverse events
- Ototoxicity
- Cushingoid
- Sodium retention
- Hypertension
- Exophthalmos
- Tendon rupture
- Fluid retention
- Vertigo
- Perioral dermatitis
- Epidural lipomatosis
- Central serous chorioretinopathy
- Hypertrichosis
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