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PHENELZINE
SynDRA canonical compound SYN0003646 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | AOC3 |
|---|
| Mechanism of action | Monoamine oxidase inhibitor |
|---|
| Indication | depression |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- MAOB
- MAOA
- AOC3
- SLC6A3
- SLC6A4
- CYP2C8
- SLC6A2
- IDO1
- Maob
- Maoa
- KDM1A
- ABAT
Mechanisms of action (all sources)
- Monoamine oxidase inhibitor
- MAOA INHIBITOR
- MAOB INHIBITOR
- AOC3 INHIBITOR
- CYP2C8 INHIBITOR
- SLC6A3 INHIBITOR
- MAOA IRREVERSIBLE INHIBITOR
- MAOB IRREVERSIBLE INHIBITOR
- SLC6A2 INHIBITOR
- SLC6A4 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR1A
- ESR1
- DRD3
- PTGS1
- ACHE
- MAPK3
- NPC1
- NFKB1
- NFE2L2
- MPHOSPH8
- MMP9
- MMP1
- MC5R
- MC4R
- MC3R
- MAPT
- MAPK14
- NPY2R
- MAPK1
- LMNA
- LCK
- KDR
- KDM4E
- KDM4A
- KCNH2
- HTR6
- HTR2C
- HTR2B
- HTR2A
- NPY1R
- NR3C1
- HRH3
- RGS4
- TSHR
- TP53
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- AHR
- GLI3
- SC6A4
- SC6A3
- SC6A2
- RARA
- PRGR
- NR1I2
- NF2L2
- MDR1
- LOX12
- HTT
- ESRRA
- AICDA
- CP3A7
- CP3A4
- CP2D6
- CP2CJ
- CP2C9
- CP2C8
- CP1A2
- ANDR
- ALR
- ALOX12
- TAAR1
Drug classes
- Monoamine Oxidase Inhibitors
- Antidepressive Agents
- Central Nervous System Agents
- Enzyme Inhibitors
- Psychotropic Drugs
- Monoamine Oxidase Inhibitor
ATC classes
Cross-references
Synonyms
- NARDIL
- Nardil
- PHENELZINE SULFATE
- 1-hydrazino-2-phenylethane
- 2-phenylethylhydrazine
- phenalzine
- phenethylhydrazine
- phenelzine sulfate
- Fenelzina
- Fenelzyna
- Fenelzyne
- Phenelezine
- Phenelzinum
- Phenethylhydrazine
- Phenylethylhydrazine
- Fenelzyna [Polish]
- Fenelzyne [Polish]
- W1544
- Beta-Phenylethylhydrazine
- Fenelzina [INN-Spanish]
- Nardelzine (TN)
- Nardil (TN)
- Phenelzine (BAN)
- Phenelzine [INN:BAN]
- Phenelzinum [INN-Latin]
- Phenylethyl hydrazine-HCl
- W 1544-A
- 1-Hydrazino-2-phenylethane
- 2-Phenethylhydrazine
- 2-Phenylethylhydrazine
- Hydrazine, (2-phenylethyl)-
- beta-Phenylethylhydrazine
- phenethyl hydrazine
- (2-phenylethyl)hydrazine
- HYDRAZINE, PHENETHYL-
- (2-Phenyl-ethyl)-hydrazine
- CHEMBL1089
- CHEBI:8060
Reported adverse events
- Ataxia
- Constipation
- Dizziness
- Leukopenia
- Pruritus
- Urinary retention
- Weight
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