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MESORIDAZINE
SynDRA canonical compound SYN0003645 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | HTR2A |
|---|
| Mechanism of action | Dopamine receptor antagonist |
|---|
| Indication | schizophrenia |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- DRD2
- HTR2A
- DRD1
- DRD3
- HTR1A
- HTR2C
- CHRM1
- CHRM2
- CHRM3
- CHRM4
- CHRM5
- DRD4
Mechanisms of action (all sources)
- Dopamine receptor antagonist
- DRD2 ANTAGONIST
- Dopamine D2 receptor antagonist
- HTR2A ANTAGONIST
- Serotonin 2a (5-HT2a) receptor antagonist
- HTR1A ANTAGONIST
- HTR2C ANTAGONIST
- DRD1 ANTAGONIST
- DRD3 ANTAGONIST
- DRD2 AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADRA1A
- ADRA2A
- OPRM1
- ACHE
- MAOA
- TBXA2R
- SLC6A4
- SLC6A3
- SLC6A2
- SAMHD1
- PTGS1
- PGR
- PDE4A
- PDE3A
- MAPT
- KDM4E
- KDR
- ADORA3
- IDH1
- HTR2B
- HRH3
- HDAC6
- GMNN
- F2
- ESR1
- EHMT2
- ATXN2
- AR
- TDP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT1A
- 5HT2C
- ACM1
- ACM4
- ACM5
- CP2D6
- CP3A7
- GLI3
- GPR32
- IL1B
- MDR1
- NR1I2
- RARA
- RGS4
Drug classes
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Dopamine Agents
- Dopamine Antagonists
- Neurotransmitter Agents
- Psychotropic Drugs
- Tranquilizing Agents
- Phenothiazine
ATC classes
Cross-references
Synonyms
- SERENTIL
- mesoridazine besilate
- thioridazine-2-sulfoxide
- mesoridazine besylate
- Mesoridazina
- Thioridazine-2-sulfoxide
- NC-123
- NSC-186066
- TPS-23
- Lidanar
- Calodal
- Lidanil
- Mesoridazinum
- Serentil
- Serentil Concentrate
- Thioridazien thiomethyl sulfoxide
- Thioridazine monosulfoxide analog
- Thioridazine thiomethyl sulfoxide
- Tps23
- Lidanar (TN)
- Mesoridazina [INN-Spanish]
- Mesoridazinum [INN-Latin]
- Serentil (TN)
- Mesoridazine (USAN/INN)
- Mesoridazine [USAN:BAN:INN]
- T-2-SO
- THD-2-SO
- Thioridazine 2-sulfoxide
- TPS 23
- Mesoridazine free base
- NSC186066
- CHEMBL1088
- 5XE4NWM740
- CHEBI:6780
- NSC 186066; Serentil; TPS 23
- NCGC00163157-01
- 5588-33-0 (FREE BASE)
- CAS-5588-33-0
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