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FINGOLIMOD
SynDRA canonical compound SYN0003587 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | S1PR4 |
|---|
| Mechanism of action | Sphingosine 1 phosphate receptor agonist |
|---|
| Indication | multiple sclerosis |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- S1PR1
- S1PR5
- S1PR3
- S1PR4
- S1PR2
- SPHK1
- CYP2E1
- CYP4F2
- DRD3
- SGPL1
- Sgpl1
- Trpm7
Mechanisms of action (all sources)
- Sphingosine 1 phosphate receptor agonist
- S1PR5 AGONIST
- Sphingosine 1-phosphate receptor agonist
- S1PR2 AGONIST
- S1PR4 AGONIST
- S1PR3 AGONIST
- S1PR1 AGONIST
- S1PR5 BINDING AGENT
- Sphingosine 1-phosphate receptor binding agent
- S1PR2 BINDING AGENT
- S1PR4 BINDING AGENT
- S1PR3 BINDING AGENT
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- GPR183
- CERS2
- TNNC1
- AGTR1
- HDAC6
- TDG
- STAT3
- SPHK2
- SMUG1
- OGG1
- NTHL1
- NEIL2
- NEIL1
- GPR35
- APLNR
- ADRA2A
- GPR119
- GLP1R
- FPR2
- FFAR4
- CX3CR1
- ADRB2
- C5AR1
- ADGRF1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ATXN2
- IFNG
- KSYK
- NSD2
- NTM1A
- NTMT1
- SYK
Drug classes
- Immunologic Factors
- Immunosuppressive Agents
- Sphingosine 1 Phosphate Receptor Modulators
- Sphingosine 1-Phosphate Receptor Modulators
- Sphingosine 1-phosphate Receptor Modulator
- Immunosuppressant
ATC classes
- L04A · IMMUNOSUPPRESSANTS
Cross-references
Synonyms
- FINGOLIMOD HYDROCHLORIDE
- GILENYA
- Gilenya
- TASCENSO ODT
- Tascenso
- FTY-720
- fingolimod hydrochloride
- gilenya
- fingolimod HCl
- GSK618334
- Fingolimod hydrochloride
- FTY720
- Fingolimod HCl
- Gilenia
- Fty 720
- Fingolimod (FTY720) HCl
- Fingolimod (hydrochloride)
- UNII-G926EC510T
- Fingolimod hydrochloride [USAN]
- CHEBI:63112
- G926EC510T
- AK-33554
- Fingolimod-d4 Hydrochloride
- 3QN8BYN5QF
- Fty-720
- fingolimodum
- CHEBI:63115
- RefChem:57690
- DTXCID0089854
- L04AA27
- Fingolimod [INN]
- MFCD14705150
- C19H33NO2
- Gilenya (TN)
- Fingolimod (INN)
- s5950
- UNII-3QN8BYN5QF
- Fingolimod (Standard)
Reported adverse events
- Bradycardia
- Cough
- Headache
- Hypersensitivity
- Hypertension
- Infection
- Nausea
- Bradyarrhythmia
- Alopecia
- Lymphopenia
- Seizure
- T-cell lymphoma
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