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TIZANIDINE
SynDRA canonical compound SYN0003529 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ADRA2A | ADRA2B | ADRA2C | CYP1A2 | NISCH |
|---|
| Mechanism of action | adrenergic receptor agonist |
|---|
| Indication | spasms |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- ADRA2B
- ADRA2A
- ADRA2C
- NISCH
- ADRA1A
- CYP1A2
- TADA2A
Mechanisms of action (all sources)
- ADRA2A AGONIST
- Adrenergic receptor alpha-2 agonist
- ADRA2C AGONIST
- ADRA2B AGONIST
- TADA2A AGONIST
- adrenergic receptor agonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HRH2
- ADGRF1
- LMNA
- NPY1R
- NEIL2
- NEIL1
- MUTYH
- MPG
- MLNR
- MC4R
- MC3R
- MAOA
- KCNH2
- ADORA1
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH1
- HDAC6
- NPY2R
- NR3C1
- NTSR1
- OGG1
- TDG
- TBXA2R
- TACR1
- SMUG1
- SLC6A4
- SLC6A3
- SLC6A2
- SLC29A1
- SAMHD1
- S1PR1
- RGS4
- PTGS2
- POLI
- PGR
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Adrenergic alpha2-Agonists
- Central alpha-2 Adrenergic Agonist
- Anticonvulsants
- Adrenergic Agents
- Adrenergic Agonists
- Adrenergic alpha-2 Receptor Agonists
- Adrenergic alpha-Agonists
- Analgesics
- Central Nervous System Agents
- Muscle Relaxants, Central
- Neuromuscular Agents
- Neurotransmitter Agents
ATC classes
- M03B · MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Cross-references
Synonyms
- ONTRALFY
- Ontralfy
- TIZANIDINE HYDROCHLORIDE
- ZANAFLEX
- Zanaflex
- DS 103-282
- tizanidine hydrochloride
- tizanidine HCl
- AN021
- DS103-282
- Tizanidina
- Sirdalud
- Ternelin
- Tizanidinum
- Sirdalud (TN)
- Tizanidina [INN-Spanish]
- Tizanidine (INN)
- Tizanidine [INN:BAN]
- Tizanidinum [INN-Latin]
- Zanaflex (TN)
- 6AI06C00GW
- DTXCID203679
- CHEBI:63629
- RefChem:58565
- M03BX02
- MFCD00865192
- NCGC00160529-01
- TIZANIDINE [INN]
- CAS-51322-75-9
- BRN 0618691
- UNII-6AI06C00GW
- Tizanidine?
- SR-01000765392
- Tizanidine (Standard)
- TIZANIDINE [MI]
- TIZANIDINE [VANDF]
- TIZANIDINE [WHO-DD]
- SCHEMBL60334
Reported adverse events
- Constipation
- Vomiting
- Dizziness
- Bradycardia
- Amblyopia
- Asthenia
- Dyskinesia
- Infection
- Nervousness
- Pharyngitis
- Rhinitis
- Somnolence
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