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LOFEPRAMINE
SynDRA canonical compound SYN0003513 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | SLC6A4 |
|---|
| Mechanism of action | Norepinephrine reuptake inhibitor |
|---|
| Indication | depression |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- SLC6A2
- SLC6A4
- HTR1A
- ADRA1A
- CHRM1
- CHRM2
- CHRM3
- CHRM4
- CHRM5
- DRD2
- HRH1
- HTR2C
Mechanisms of action (all sources)
- Serotonin reuptake inhibitor
- Norepinephrine reuptake inhibitor
- SLC6A2 INHIBITOR
- SLC6A4 INHIBITOR
- serotonin–norepinephrine reuptake inhibitor (SNRI)
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- OPRK1
- HTR2A
- ADRA2B
- KCNH2
- DRD3
- CNR1
- NR1I2
- ABL1
- HTR2B
- HTR3A
- MAPK1
- MC3R
- MLNR
- NPY1R
- NR3C1
- OPRD1
- OPRM1
- HRH2
- PDE3A
- PDE4D
- PGR
- PTGS2
- RET
- SLC29A1
- SLC6A3
- SMPD1
- TBXA2R
- TDP1
- TRIM24
- USP1
- HRH3
- GSK3B
- HDAC6
- ADORA1
- ADORA2A
- ADORA3
- ADRA2A
- ADRA2C
- ADRB1
- ADRB2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- GLI3
- SC6A4
- SC6A2
- PRGR
- NTMT1
- NTM1A
- NF2L2
- M4K2
- KSYK
- JUN
- GPR32
- GEMI
- ACM1
- CP3A7
- CP3A4
- CP2D6
- CP2CJ
- CP2C9
- CP1A2
- APAF
- ANDR
- ALR
- AHR
- SYK
Drug classes
- Antidepressive Agents
- Antidepressive Agents, Tricyclic
- Central Nervous System Agents
- Psychotropic Drugs
ATC classes
Cross-references
Synonyms
- lopramine
- lofepramine hydrochloride
- lopramine hydrochloride
- WHR-2908A
- lofepramine HCl
- lopramine HCl
- Lofepramina
- Lopramine
- DB-2182
- Leo-640
- Lofepraminum
- OCA4JT7PAW
- CHEBI:47782
- Deftan
- RefChem:153943
- DTXCID303220
- N06AA07
- Leo 640
- Gamanil
- Lofepramine (INN)
- LOFEPRAMINE [INN]
- C26H27ClN2O
- Lofepramine [INN:BAN]
- Lofepraminum [INN-Latin]
- Lofepramina [INN-Spanish]
- HSDB 7184
- UNII-OCA4JT7PAW
- NCGC00166397-02
- EINECS 245-396-8
- Lomont
- Gamanil (Salt/Mix)
- Gamonil (Salt/Mix)
- Timelit (Salt/Mix)
- Tymelyt (Salt/Mix)
- LOFEPRAMINE [MI]
- LOFEPRAMINE [JAN]
- LOFEPRAMINE [HSDB]
- SCHEMBL35028
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