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BUMETANIDE
SynDRA canonical compound SYN0003511 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SLC12A2 |
|---|
| Mechanism of action | Solute carrier family member inhibitor |
|---|
| Indication | congestive heart failure | edema |
|---|
| Disease area | cardiology |
|---|
All known targets
- SLC12A1
- SLC12A2
- GPR35
- ATP1A1
- CFTR
- SLC12A4
- SLC12A5
Mechanisms of action (all sources)
- Solute carrier family member inhibitor
- SLC12A1 INHIBITOR
- Sodium-(potassium)-chloride cotransporter 2 inhibitor
- SLC12A2 INHIBITOR
- GPR35 AGONIST
- SLC12A1 BLOCKER
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CA9
- CA5B
- CA1
- CA12
- CA14
- CA2
- CA5A
- CA4
- CA6
- CA7
- NTSR1
- MLNR
- NFE2L2
- NPSR1
- NPY1R
- NPY2R
- MC4R
- MC3R
- MBNL1
- MAPK1
- MAOA
- LMNA
- HTR2B
- HPGD
- HRH1
- HRH2
- HRH3
- HSD17B10
- HTR1A
- HTR2A
- HTR2C
- KDM4E
- HTR3A
- HTR5A
- HTR6
- HTR7
- IDH1
- KAT2A
- KCNH2
- NR3C1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- BAP1
- M4K2
- MDR1
- NTM1A
- S12A2
- S12A5
Drug classes
- Loop Diuretic
- Diuretics
- Membrane Transport Modulators
- Natriuretic Agents
- Sodium Potassium Chloride Symporter Inhibitors
ATC classes
- C03C · HIGH-CEILING DIURETICS
- DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION
Cross-references
Synonyms
- BUMEX
- Bumex
- ENBUMYST
- Enbumyst
- bumethanide
- bufenox
- Bumetanida
- PF-1593
- PF1593
- RO-10-6338
- RO-106338
- RO10-6338
- S-95008.
- S95008.
- Betinex
- Burinex
- Lixil
- Aquazone
- Bumedyl
- Bumetanidum
- Bumethanide
- Burine
- Butinat
- Cambiex
- Diurama
- Drenural
- Fontego
- Fordiuran
- Lunetoron
- Miccil
- Segurex
- Yurinex
- AstraZeneca Brand of Bumetanide
- Atlantis Brand of Bumetanide
- Bumetanide AstraZeneca Brand
- Bumetanide Atlantis Brand
- Bumetanide Farmacusi Brand
Reported adverse events
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