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OXAPROZIN
SynDRA canonical compound SYN0003504 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PTGS2 |
|---|
| Mechanism of action | Cyclooxygenase inhibitor |
|---|
| Indication | osteoarthritis | rheumatoid arthritis |
|---|
| Disease area | rheumatology |
|---|
All known targets
- PTGS1
- PTGS2
- EPHX2
- C5
- Ephx2
- FPR1
- NR4A2
- RXRA
- RXRB
- RXRG
- SHMT2
Mechanisms of action (all sources)
- Cyclooxygenase inhibitor
- PTGS2 INHIBITOR
- PTGS1 INHIBITOR
- EPHX2 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HRH1
- HTR2A
- DRD3
- ADRA1A
- HTR2C
- PPARG
- DRD2
- CHRM1
- ABCC4
- NFE2L2
- MMP9
- MPHOSPH8
- NPY2R
- NPY1R
- MLNR
- NR1H2
- NR1H3
- NR1H4
- NR3C1
- MMP1
- MC4R
- MC5R
- NR4A3
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- KDM4E
- KCNH2
- HTR6
- HTR3A
- HTR2B
- NR4A1
- OPRD1
- NTSR1
- SIGMAR1
- VDR
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Cyclooxygenase Inhibitors
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Enzyme Inhibitors
- Peripheral Nervous System Agents
- Sensory System Agents
- Nonsteroidal Anti-inflammatory Drug
ATC classes
- M01A · ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Cross-references
Synonyms
- COXANTO
- Coxanto
- DAYPRO
- DAYPRO ALTA
- Daypro
- alvo
- oxaprozin potassium
- WY 21743
- Oxaprozine
- Oxaprozina
- NSC-310839
- WY-21,743
- WY-21743
- Actirin
- Alvo
- Danoprox
- Dayrun
- Deflam
- Oxaprozinum
- Voir
- Xopane
- Apotex brand of oxaprozin
- CSC brand of oxaprozin
- Pfizer brand of oxaprozin
- Rhoxalpharma brand of oxaprozin
- TRB brand of oxaprozin
- Lyl)propenoic acid
- NCI310839
- O 9637
- Apo-Oxaprozin
- Daypro (TN)
- Duraprox (TN)
- Oxaprozina [INN-Spanish]
- Oxaprozine [INN-French]
- Oxaprozinum [INN-Latin]
- Rhoxal-oxaprozin
- Oxaprozin (JP15/USAN/INN)
Reported adverse events
- Bleeding
- GI bleed
- Perforation
- Ulceration
- Elderly
- Stevens-Johnson syndrome
- Hepatotoxicity
- Hypertension
- Abdominal pain
- Agranulocytosis
- Alopecia
- Anxiety
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