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TRICHLORMETHIAZIDE
SynDRA canonical compound SYN0003423 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | SLC12A1 |
|---|
| Mechanism of action | Chloride channel antagonist |
|---|
| Indication | edema | hypertension |
|---|
| Disease area | cardiology |
|---|
All known targets
- SLC12A1
- SLC12A3
- CA1
- CA12
- CA14
- CA2
- CA4
- CA5A
- CA5B
- CA6
- CA7
- CA9
Mechanisms of action (all sources)
- Chloride channel antagonist
- SLC12A3 INHIBITOR
- Thiazide-sensitive sodium-chloride cotransporter inhibitor
- chloride channel blocker
- SLC12A1 BLOCKER
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- KDR
- MMP9
- MMP1
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- KCNH2
- NPY2R
- HTR6
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- NPY1R
- NR3C1
- ADORA1
- SIGMAR1
- TBXAS1
- TBXA2R
- TARDBP
- TACR2
- TACR1
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC6A3
- SLC6A2
- SAMHD1
- OPRD1
Drug classes
- Antihypertensive Agents
- Cardiovascular Agents
- Diuretics
- Membrane Transport Modulators
- Natriuretic Agents
- Sodium Chloride Symporter Inhibitors
ATC classes
- C03A · LOW-CEILING DIURETICS, THIAZIDES
- DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION
Cross-references
Synonyms
- METAHYDRIN
- METATENSIN #2
- METATENSIN #4
- NAQUA
- NAQUIVAL
- TRICHLOREX
- TRICHLORMAS
- TRICHLORMETHIAZIDE W/ RESERPINE
- triclormetiazide
- hydrotrichlorothiazide
- trichlormetazid
- trichlormethiazid
- trichloromethiazide
- Triclormetiazida
- Trichloromethiazide
- NSC-61560
- Metahydrin
- Naqua
- Trichlorex
- Trichlormas
- Trichlormethiazide component of metatensin
- Trichlormethiazide component of naquival
- Achletin
- Anistadin
- Aponorin
- Aquazide
- Carvacron
- Chlopolidine
- Cretonin
- Diurazida
- Diurese
- Diuroral;Esmarin
- Eurinol
- Fluitran
- Flurese
- Flutra
- Gangesol
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