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MOZAVAPTAN
SynDRA canonical compound SYN0003368 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | AVPR2 |
|---|
| Mechanism of action | Vasopressin receptor antagonist |
|---|
| Indication | hyponatremia |
|---|
| Disease area | endocrinology |
|---|
All known targets
- AVPR2
- AVPR1A
- AVPR1B
- Avpr1a
- Avpr1b
- Avpr2
- OXTR
Mechanisms of action (all sources)
- Vasopressin receptor antagonist
- AVPR2 ANTAGONIST
- Vasopressin V2 receptor antagonist
- AVPR1A ANTAGONIST
- AVPR1B ANTAGONIST
- AVPR2 INVERSE AGONIST
- AVPR1B INHIBITOR
- AVPR2 INHIBITOR
- AVPR1A INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR1A
- OPRM1
- SLC6A4
- HTR2B
- KCNH2
- KDR
- MAOA
- MBD4
- MPG
- MUTYH
- NEIL1
- NTHL1
- ABCB11
- HRH3
- PDE4A
- PGR
- PTGS1
- S1PR1
- SLC6A2
- SLC6A3
- TBXA2R
- TDG
- PDE3A
- HDAC6
- ACHE
- CHRM1
- ADGRF1
- ADORA3
- ADRA1A
- ADRA2A
- ADRB2
- AGTR1
- APLNR
- AR
- C5AR1
- CHRM2
- GPR35
- CX3CR1
- DRD1
- DRD3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- CASP3
- CASP7
- CP3A4
- CP3A7
- ESRRA
- GLI3
- KSYK
- NR1I2
- NSD2
- RARA
- SYK
- TP53
- V1AR
Drug classes
- Antidiuretic Hormone Receptor Antagonists
- Natriuretic Agents
Cross-references
Synonyms
- mozavaptan hydrochloride
- physulime
- OPC-31260
- mozavaptan HCl
- Mozavaptane
- Opc 31260
- Mozavaptan [INN]
- CHEMBL420762
- OPC31260
- 5-Dimethylamino-1-(4-(2-methylbenzoylamino)benzoyl)-2,3,4,5-tetrahydro-1H-benzazepine
- N-(4-(5-(dimethylamino)-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-2-methylbenzamide
- N-(4-((5-(Dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl)phenyl)-2-methylbenzamide
- N-(4-(((5RS)-5-(Dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl)phenyl)-2-methylbenzamide
- C27H29N3O2
- Mozavaptan free base
- 137975-06-5 (free base)
- N-[4-[5-(dimethylamino)-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]phenyl]-2-methylbenzamide
- 17OJ42922Y
- Benzamide, N-(4-((5-(dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl)phenyl)-2-methyl-
- UNII-17OJ42922Y
- Benzamide, N-[4-[[5-(dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl]phenyl]-2-methyl-
- MOZAVAPTAN [MI]
- MOZAVAPTAN [MART.]
- MOZAVAPTAN [WHO-DD]
- OPC31260l
- GTPL2197
- SCHEMBL1649322
- DTXSID8057641
- BDBM35714
- CHEBI:135694
- BCP06718
- EX-A1127
- Tox21_113926
- MFCD00908918
- s2920
- AKOS015895761
- AC-4255
- CCG-268974
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