← SynDRA
TYRPHOSTIN 23
SynDRA canonical compound SYN0003279 — structure-anchored drug synonym record
| Clinical phase | Preclinical |
|---|
| Primary target(s) | EGFR |
|---|
| Mechanism of action | EGFR inhibitor | tyrosine kinase inhibitor |
|---|
All known targets
Mechanisms of action (all sources)
- EGFR INHIBITOR
- tyrosine kinase inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CDK2
- PTK2B
- ACHE
- OPRD1
- MMP9
- MPHOSPH8
- NEK2
- NEK6
- NFKB1
- NPY1R
- NPY2R
- NR3C1
- OPRK1
- MC5R
- OPRM1
- OXSR1
- PAK4
- PAK5
- PAK6
- PBK
- PDE5A
- PDPK1
- PIM1
- MMP1
- MC4R
- PIM3
- MC3R
- HTR2C
- HTR6
- JAK1
- JAK2
- KCNH2
- KDM4A
- KDM4C
- KDM4E
- L3MBTL1
- LCK
- LMNA
- MAOA
- MAP2K2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ADCY9
- ALR
- PPBT
- PHGDH
- NTM1A
- NSD2
- MITF
- LOX12
- LMBL1
- HS90B
- HS90A
- GLSK
- GLI3
- CP3A4
- CP2C9
- CP1A2
- CCNE1
- RARA
Drug classes
- Antineoplastic Agents
- Enzyme Inhibitors
Cross-references
Synonyms
- RG 50810
- Tyrphostin A23
- AG-18
- (3,4-Dihydroxybenzylidene)malononitrile
- Tyrphostin AG18
- Tyrphostin RG50810
- 2-(3,4-dihydroxybenzylidene)malononitrile
- UNII-RV0GCD31OJ
- alpha-Cyano-(3,4-dihydroxy)cinnamonitrile
- 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile
- Propanedinitrile,2-[(3,4-dihydroxyphenyl)methylene]-
- ag18
- (3,4-Dihydroxyphenyl)methylene propanedinitrile
- RV0GCD31OJ
- C10H6N2O2
- NCGC00016043-03
- (3,4-dihydroxybenzylidene)propanedinitrile
- DSSTox_CID_25215
- BRD-K49657628
- tyrphostin-AG-18
- 3,4-dihydroxybenzylidenemalononitrile
- RefChem:900829
- MFCD00133899
- AG 18 (Tyrphostin 23)
- ((3,4-Dihydroxyphenyl)methylene)-Propanedinitrile
- DTXCID7025215
- CAS-118409-57-7
- SR-01000075506
- Tocris-0493
- BiomolKI_000011
- Lopac-T-7165
- BiomolKI2_000021
- cid_2052
- Lopac0_001160
- Oprea1_072726
- Tyrphostin 23, >=98%
- MLS002153315
- SCHEMBL241922
Look up TYRPHOSTIN 23 in the interactive SynDRA portal →