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SIVELESTAT
SynDRA canonical compound SYN0003265 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | CELA1 | ELANE |
|---|
| Mechanism of action | elastase inhibitor |
|---|
| Indication | acute lung injury |
|---|
| Disease area | pulmonary |
|---|
All known targets
Mechanisms of action (all sources)
- ELANE INHIBITOR
- Leukocyte elastase inhibitor
- elastase inhibitor
- CELA1 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- FAP
- ADORA1
- NPY1R
- HRH3
- HTR1A
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- KCNH2
- KLK1
- MAOA
- MC3R
- MLNR
- NR1I2
- HRH1
- NR3C1
- OPRD1
- OPRK1
- OPRM1
- PDE3A
- PDE4D
- PGR
- PLAU
- PTGS2
- SLC6A2
- SLC6A3
- SLC6A4
- HRH2
- HDAC6
- ADORA2A
- GHSR
- ADORA3
- ADRA2A
- ADRA2B
- ADRA2C
- ADRB1
- ADRB2
- AGTR1
- AVPR1A
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Enzyme Inhibitors
- Protease Inhibitors
- Serine Proteinase Inhibitors
Cross-references
Synonyms
- sivelestat sodium hydrate
- elaspol
- sivelestat sodium
- LY-544349
- LY544349
- ONO-5046
- Sivelestat sodium hydrate
- Sivelestat sodium tetrahydrate
- Elaspol
- Sodium sivelestat
- EI546 sodium
- UNII-737RR8Y409
- Sivelestat (sodium tetrahydrate)
- LY544349 sodium
- Sivelestat sodium [USAN]
- Sivelestat sodium (USAN)
- 737RR8Y409
- DSSTox_CID_26727
- DSSTox_RID_81857
- DSSTox_GSID_46727
- sodium 2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate tetrahydrate
- LY544349 Sodium Hydrate
- Elaspol (TN)
- CAS-201677-61-4
- NCGC00167577-01
- AC1L4KMF
- Sivelestat sodium hydrate (JAN)
- Sodium ((2-(((4-((2,2-dimethylpropanoyl)oxy)phenyl)sulfonyl)amino)benzoyl)amino)acetate tetrahydrate
- Glycine, N-(2-(((4-(2,2-dimethyl-1-oxopropoxy)phenyl)sulfonyl)amino)benzoyl)-, monosodium salt, tetrahydrate
- UNII-DWI62G0P59
- 2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid
- Elastase Inhibitor IV
- C20H22N2O7S
- N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid
- Sivelestat (ONO-5046)
- CHEMBL76688
- LY 544349
- DWI62G0P59
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