← SynDRA

TIAGABINE

SynDRA canonical compound SYN0003258 — structure-anchored drug synonym record

All known targets

• SLC6A1
• CYP2C19
• Slc6a1
• Slc6a12

Mechanisms of action (all sources)

• GABA uptake inhibitor
• SLC6A1 INHIBITOR
• GABA transporter 1 inhibitor

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• ESR1
• ABL1
• PDE3A
• HTR1A
• HTR2B
• KCNH2
• KDR
• MAOA
• MAPK1
• OPRM1
• PDE4A
• HDAC6
• PGR
• PTGS1
• SLC6A11
• SLC6A2
• SLC6A3
• SLC6A4
• TBXA2R
• TDP1
• HRH3
• GSK3B
• ACHE
• CDK2
• ADORA3
• ADRA1A
• ADRA2A
• AR
• AURKA
• BRD4
• BRPF1
• CHRM1
• GMNN
• CHRM2
• CSNK1D
• CYP3A4
• DRD1
• DRD3
• F2
• FGFR2

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• CP3A7
• KCMB1
• TP53

Drug classes

• Anticonvulsants
• Central Nervous System Agents
• GABA Agents
• GABA Uptake Inhibitors
• Membrane Transport Modulators
• Neurotransmitter Agents
• Neurotransmitter Uptake Inhibitors
• Anti-epileptic Agent

ATC classes

• N03A · ANTIEPILEPTICS

Cross-references

• PubChem CID: 60648
• ChEMBL: CHEMBL1027
• DrugBank: DB00906
• ChEBI: CHEBI:9586
• KEGG: D02097
• RxNorm: 31914
• PDB: TGI
• Wikipedia: Tiagabine
• TTD: D0ED7U
• LINCS BRD: BRD-K60160658

Synonyms

• GABITRIL
• Gabitril
• TIAGABINE HYDROCHLORIDE
• (R)-Tiagabine
• gabatril
• tiagabine hydrochloride
• tiagabine HCl
• Tiagabina
• Abbott-70569-1
• A-70569-1
• ABBOTT-70569 FREE BASE
• ABBOTT-705691 FREE BASE
• ABT-569 FREE BASE
• NNC-050328 FREE BASE
• NO-050328 FREE BASE
• Tiagabinum
• Tiagabinum [INN-Latin]
• Tiagabina [INN-Spanish]
• Tiagabine [INN:BAN]
• Tiagabine [INN]
• Abbott-70569
• UNII-Z80I64HMNP
• Tiagabine (INN)
• ABBOTT-70569-1
• Gabitril (TN)
• CHEMBL1027
• Z80I64HMNP
• ABT-569
• CHEBI:9586
• NO-328
• Gabatril
• NO-329
• Tiagabina [INN-Spanish];Tiagabine (INN)
• [3H]tiagabine
• NO328
• NO050328
• TGB
• NCGC00164626-01

Reported adverse events

• Agitation
• Asthenia
• Ataxia
• Cough
• Depression
• Dizziness
• Hostility
• Insomnia
• Nausea
• Nervousness
• Nystagmus
• Pain