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IFOSFAMIDE
SynDRA canonical compound SYN0003205 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PTGS1 |
|---|
| Mechanism of action | DNA alkylating agent |
|---|
| Indication | hemorrhagic cystitis | testicular carcinoma |
|---|
| Disease area | oncology | urology |
|---|
All known targets
- CYP2A6
- CYP2B6
- CYP2C18
- CYP2C19
- CYP2C8
- CYP2C9
- CYP3A4
- CYP3A5
- CYP3A7
- PTGS1
- DNMT1
Mechanisms of action (all sources)
- DNA alkylating agent
- DNMT1 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- NPY2R
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- KCNH2
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- NPY1R
- NR1I2
- ADORA1
- NR3C1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SLCO1B1
- SLC6A4
- SLC6A3
- SLC6A2
- SLC29A1
- SIGMAR1
- SAMHD1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Alkylating Activity
- Alkylating Drug
- Alkylating Agents
- Antineoplastic Agents
- Antineoplastic Agents, Alkylating
- Noxae
ATC classes
Cross-references
Synonyms
- IFEX
- IFEX/MESNEX KIT
- IFOSFAMIDE/MESNA KIT
- Ifex
- holoxan
- ifomide
- ifosfamid
- ifosfomide
- ifosphamide
- iphosphamide
- isoendoxan
- isofosfamide
- isophosphamide
- mitoxana
- naxamide
- Ifosfamida
- Isocyclophosphamide
- Isophosphamide
- MJF-9325
- NSC-109724
- Z-4942
- Z4942
- Ifsofamide
- Mitoxana
- Cyfos
- Holoxan
- Ifosfamid
- Ifosfamidum
- Ifosphamide
- Iphosphamid
- Iphosphamide
- Isoendoxan
- Isofosfamide
- Isosfamide
- Naxamide
- Ifosfamide Sterile
- Iso-Endoxan
Reported adverse events
- Myelosuppression
- Hemorrhagic cystitis
- Hemorrhagic cyst
- Nephrotoxicity
- CNS toxicity
- Alopecia
- Constipation
- Dermatitis
- Fanconi syndrome
- Fatigue
- Hypertension
- Hypotension
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