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PERHEXILINE
SynDRA canonical compound SYN0003198 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | CPT2 |
|---|
| Mechanism of action | Carnitine palmitoyltransferase inhibitor |
|---|
| Indication | angina pectoris |
|---|
| Disease area | cardiology |
|---|
All known targets
- CPT2
- CPT1B
- CPT1A
- MTOR
- KCNH2
- SIGMAR1
- SCN5A
- FYN
- EGFR
- Cpt2
- Cpt1b
- Cpt1a
Mechanisms of action (all sources)
- Carnitine palmitoyltransferase inhibitor
- CPT1B INHIBITOR
- Carnitine O-palmitoyltransferase 1, muscle isoform inhibitor
- CPT2 INHIBITOR
- Carnitine palmitoyltransferase 2 inhibitor
- MTOR inhibitor
- Serine/threonine-protein kinase mTOR inhibitor
- potassium channel blocker
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR2
- SLC6A3
- NR1I2
- HTR1A
- DRD1
- CASP1
- CHRM2
- ESR1
- GHSR
- MC3R
- MMP9
- MMP1
- ABCB11
- NFE2L2
- NLRP1
- NPY1R
- NPY2R
- NR3C1
- NPSR1
- MLNR
- OPRK1
- MITF
- MC5R
- MC4R
- MAPT
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- KDR
- OPRD1
- PDE3A
- OPRM1
- HTT
- VDR
- USP1
- UBE2N
- TP53
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- NSD2
- KCNQ1
- KSYK
- M4K2
- MDM2
- MDM4
- MDR1
- MLP3A
- OXYR
- ACM4
- PRGR
- RAD52
- RARA
- SMAD2
- SYK
- TAAR1
- TBB5
- JUN
- IL1B
- IFNG
- IDHC
- ANDR
- APAF
- BARD1
- BRCA1
- CASP3
- CASP7
- CFTR
- CP19A
- CP2CJ
- CP2D6
- CP3A7
- CREB1
- ESRRA
- GLI3
- GNA15
- TSHR
Drug classes
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Membrane Transport Modulators
- Vasodilator Agents
ATC classes
- C08E · NON-SELECTIVE CALCIUM CHANNEL BLOCKERS
Cross-references
Synonyms
- perhexiline maleate
- Perhexilina
- Perhexilene
- Perhexilinum
- Perhexilline
- Perhexilina [INN-Spanish]
- Perhexiline (INN)
- Perhexiline [INN:BAN]
- Perhexilinum [INN-Latin]
- (+)-2-(2,2-Dicyclohexylethyl)piperidine
- (-)-2-(2,2-Dicyclohexylethyl)piperidine
- 2-(2,2-Dicyclohexylethyl)piperidine
- Piperidine, 2-(2,2-dicyclohexylethyl)-
- KU65374X44
- CHEBI:35553
- RefChem:860305
- DTXCID603439
- C08EX02
- perhexilline
- PERHEXILINE [INN]
- EINECS 229-569-5
- UNII-KU65374X44
- 2-[2,2-DICYCLOHEXYLETHYL]PIPERIDINE MALEATE SALT
- EINECS 252-426-3
- EINECS 254-558-7
- EINECS 254-559-2
- Spectrum_000013
- (1)-2-(2,2-Dicyclohexylethyl)piperidine
- PERHEXILINE [MI]
- Prestwick0_000286
- Prestwick1_000286
- Prestwick2_000286
- Prestwick3_000286
- Spectrum2_001539
- Spectrum3_001579
- Spectrum4_000173
- Spectrum5_001084
- Oprea1_365504
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