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XYLOMETAZOLINE
SynDRA canonical compound SYN0003137 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | ADRA2C |
|---|
| Mechanism of action | Adrenergic receptor agonist |
|---|
| Indication | allergic rhinitis | nasal congestion |
|---|
| Disease area | allergy | otolaryngology |
|---|
All known targets
- ADRA2C
- ADRA2B
- ADRA2A
- ADRA1A
- ADRA1B
- ADRA1D
- Adra1a
- Adra1b
- Adra1d
- Adra2a
- Adra2b
- Adra2c
Mechanisms of action (all sources)
- Adrenergic receptor agonist
- ADRA1A AGONIST
- Adrenergic receptor alpha agonist
- ADRA2A AGONIST
- ADRA2C AGONIST
- ADRA1D AGONIST
- ADRA1B AGONIST
- ADRA2B AGONIST
- TADA2A AGONIST
- ADRA2A PARTIAL AGONIST
- ADRA2C MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR1A
- KCNH2
- CHRM3
- DRD2
- DRD3
- HTR2A
- HTR2C
- HTR2B
- HRH3
- HTR3A
- LMNA
- MAOA
- MAPK1
- NR3C1
- MC3R
- MLNR
- MPHOSPH8
- NPY1R
- NR1I2
- MAPT
- ADORA1
- OPRD1
- OPRM1
- TP53
- TDP1
- TBXA2R
- SMPD1
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC6A3
- SLC6A2
- PTGS2
- POLB
- PMP22
- PGR
- PDE4D
- PDE3A
- OPRK1
- HRH2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT1A
- 5HT2A
- 5HT5A
- ACM1
- CP2D6
- HTR1E
- KSYK
- NSD2
- SYK
Drug classes
- Cardiovascular Agents
- Nasal Decongestants
- Respiratory System Agents
- Vasoconstrictor Agents
ATC classes
- S01G · DECONGESTANTS AND ANTIALLERGICS
- R01A · DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Cross-references
Synonyms
- rhinoxilin
- otrivine
- xylometazoline hydrochloride
- xylometazoline HCl
- Xilometazolina
- Balminil
- Xylometazoline (nasal mucoadhesive/MucoAd, congestion)
- Decongestant (nasal mucoadhesive/MucoAd, congestion), Strategic BioSciences
- Xylometazoline (nasal mucoadhesive/MucoAd, congestion), Strategic BioSciences
- WPY40FTH8K
- 2-(4-tert-Butyl-2,6-dimethylbenzyl)-2-imidazoline
- Xylomethazoline
- Otriven
- Xylometazolinum
- stas
- Nasan
- Otrivin Mentol
- Nasentropfen AL
- Nasenspray AL
- NasenSpray ratiopharm
- NasenTropfen ratiopharm
- RefChem:58081
- DTXCID6026957
- 2-(4'-tert-butyl-2',6'-dimethylphenylmethyl)imidazoline
- R01AA07
- R01AB06
- S01GA03
- Otrivin
- Otrix
- Ba 11391
- 2-IMIDAZOLINE, 2-(4-tert-BUTYL-2,6-DIMETHYLBENZYL)-
- Ba 11391; Otriven; Otrivin
- Xylometazoline (INN)
- XYLOMETAZOLINE [INN]
- F1371-0282
- 2-{[4-(tert-butyl)-2,6-dimethylphenyl]methyl}-2-imidazoline
- Xylometazoline [INN:BAN]
- Xylometazolinum [INN-Latin]
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