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ETRAVIRINE
SynDRA canonical compound SYN0003110 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CYP3A4 |
|---|
| Mechanism of action | Non-nucleoside reverse transcriptase inhibitor |
|---|
| Indication | human immunodeficiency virus (HIV-1) |
|---|
| Disease area | infectious disease |
|---|
All known targets
- CYP2C19
- CYP2C9
- CYP3A4
- ABCB1
- ABCC1
- ABCC2
- ABCC3
- ABCG2
- HIV RT
- gag-pol
- pol
- reverse transcriptas
Mechanisms of action (all sources)
- Non-nucleoside reverse transcriptase inhibitor
- HIV RT MODULATOR
- pol INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PGR
- CHRM1
- ESR1
- DRD1
- CYP1A2
- KCNH2
- SLC6A2
- PTGS1
- HTR2B
- SLC6A3
- PDE4A
- SLC6A4
- PDE3A
- SLCO1B1
- OPRM1
- MAOA
- ACHE
- HDAC6
- HTR1A
- HRH3
- ADORA1
- F2
- DRD3
- CYP2D6
- CHRM2
- CACNA1C
- AR
- ALB
- ADRA2A
- ADRA1A
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Non-Nucleoside Reverse Transcriptase Inhibitors
- Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
- Anti-Infective Agents
- Antiviral Agents
- Enzyme Inhibitors
- Nucleic Acid Synthesis Inhibitors
- Reverse Transcriptase Inhibitors
- Cytochrome P450 2C19 Inhibitors
- P-Glycoprotein Inhibitors
- Cytochrome P450 2C9 Inhibitors
- Cytochrome P450 3A Inducers
ATC classes
- J05A · DIRECT ACTING ANTIVIRALS
Cross-references
Synonyms
- INTELENCE
- Intelence
- intelence
- etravirin
- R-165335
- TMC-125
- Etravirina
- R165335
- TMC125
- DAPY deriv
- Diaminopyrimidine deriv
- Intelence (TN)
- Intelence(TM)
- R165335-TMC125
- Etravirine (JAN/USAN/INN)
- TMC-125/R-165335
- 65B
- ETR
- R 165335
- TMC 125
- 0C50HW4FO1
- TMC125 cpd
- CHEBI:63589
- etravirinum
- RefChem:57536
- DTXCID40103903
- J05AG04
- Etravirine (TMC125)
- MFCD09837879
- Etravirine-d8
- C20H15BrN6O
- UNII-0C50HW4FO1
- Etravirine CRS
- Etravirine [USAN:INN:BAN:JAN]
- Etravirine [INN]
- Etravine; Etravirine
- Etravirine (Standard)
Reported adverse events
- Rash
- Stevens-Johnson syndrome
- Hepatitis
- Lipase
- Platelet count
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