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LEVODOPA
SynDRA canonical compound SYN0003101 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | DRD3 |
|---|
| Mechanism of action | Dopamine precursor |
|---|
| Indication | Parkinson's Disease |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- DRD3
- DRD2
- DRD1
- ALOX15
- DDC
- DRD4
- DRD5
- EGFR
- FYN
- GPR143
- GPR63
- LCK
Mechanisms of action (all sources)
- Dopamine precursor
- DRD3 AGONIST
- Dopamine D3 receptor agonist
- dopamine analog
- GPR63 AGONIST
- DRD2 MODULATOR
- DRD1 AGONIST
- DRD2 AGONIST
- Dopamine receptor agonist
- ADRB1 AGONIST
- Beta-1 adrenergic receptor agonist
- DRD1 FULL AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CA5B
- CA1
- CA12
- PTGS1
- CA5A
- MAPK14
- MC3R
- MC4R
- MC5R
- MLNR
- ACHE
- MMP1
- MMP9
- MPHOSPH8
- NPY1R
- NPY2R
- NR3C1
- NTSR1
- OPRD1
- MAPK3
- MAPK1
- OPRM1
- MAOB
- HDAC6
- HIF1A
- HMGCR
- HRH1
- HRH2
- HRH3
- HSD17B10
- HTR1A
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- HTR6
- KCNH2
- KDM4A
- KDM4E
- MAOA
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- FOLH1
- IL1B
- ITPK1
- MBD2
- MITF
- NTM1A
- NUDT15
- PSIP1
- SIRT5
- UHRF1
Drug classes
- Catecholamine
- Dopamine Agents
- Neurotransmitter Agents
- Cardiotonic Agents
- Cardiovascular Agents
- Peripheral Nervous System Agents
- Protective Agents
- Sympathomimetics
- Anti-Dyskinesia Agents
- Antiparkinson Agents
- Central Nervous System Agents
- Aromatic Amino Acid
ATC classes
- N04B · DOPAMINERGIC AGENTS
- C01C · CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
Cross-references
Synonyms
- BENDOPA
- CARBIDOPA AND LEVODOPA
- CARBIDOPA, LEVODOPA AND ENTACAPONE
- CARBILEV
- CREXONT
- Crexont
- DHIVY
- DOPAR
- DUOPA
- Dhivy
- Duopa
- INBRIJA
- ledopa
- 3-Hydroxy-L-tyrosine
- DOPA
- dihydroxyphenylalanine
- Cvt-301
- Levodopa component of carbilev
- Levodopa component of parcopa
- Levodopa component of sinemet
- Levodopum
- NSC-118381
- V-1512
- Bendopa
- Brocadopa
- Dopar
- Larodopa
- Levodopa component of /carbidopa/entacapone orion
- Levodopa component of corbilta
- Levodopa component of crexont
- Levodopa component of dhivy
- Levodopa component of dopasnap
- Levodopa component of duopa
- Levodopa component of ipx-203
- Levodopa component of ipx203
- Levodopa component of rytary
- Levodopa component of stalevo
- dioleoylphosphatidic acid
Reported adverse events
- Hypersensitivity
- Rash
- Angioedema
- Ataxia
- Gastrointestinal pain
- Dyskinesia
- Nausea
- Hallucination
- Vomiting
- Depression
- Constipation
- Orthostatic hypotension
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