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EBASTINE
SynDRA canonical compound SYN0003055 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | CYP2J2 | CYP3A4 | HRH1 |
|---|
| Mechanism of action | histamine receptor antagonist |
|---|
| Indication | allergic rhinitis | urticaria |
|---|
| Disease area | allergy |
|---|
All known targets
- HRH1
- ABCB1
- HTR2B
- EGFR
- ERBB2
- FYN
- HRH2
- HTR1A
- HTR2A
- HTR2C
- ACHE
- HTR6
Mechanisms of action (all sources)
- HRH1 INVERSE AGONIST
- Histamine H1 receptor inverse agonist
- histamine receptor antagonist
- HRH1 ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- MLNR
- NR1I2
- PRKAA2
- ESR2
- OPRK1
- MMP9
- NR3C1
- NPY2R
- NPY1R
- NPC1
- NFE2L2
- MTOR
- ADORA1
- MMP1
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- OPRD1
- OPRM1
- HTT
- PDE3A
- USP1
- TDP1
- TBXAS1
- TBXA2R
- TACR1
- SNCA
- SLC29A1
- SIGMAR1
- RAB9A
- PTPRC
- PTGS2
- PTGS1
- PTAFR
- PRKCA
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- HIF1A
- SYK
- SMAD3
- SMAD2
- RARA
- NSD2
- KSYK
- JUN
- IFNG
- GLI3
- ACM1
- GEMI
- ESRRA
- CP3A7
- CP2D6
- CP2C9
- CASP7
- CASP3
- ANDR
- TSHR
Drug classes
- Histamine Agents
- Histamine Antagonists
- Histamine H1 Antagonists
- Neurotransmitter Agents
ATC classes
- R06A · ANTIHISTAMINES FOR SYSTEMIC USE
Cross-references
Synonyms
- bastel
- ebastel
- ebastin
- erostin
- kestine
- Ebastina
- LAS-W-090
- RP-64305
- Kestine
- Ebastel
- Ebastin
- Kestin
- Bactil
- LAS-W 090
- 4-(4-benzhydryloxypiperidin-1-yl)-1-(4-tert-butylphenyl)butan-1-one
- 1-(4-tert-butylphenyl)-4-[4-(diphenylmethoxy)piperidin-1-yl]butan-1-one
- LAS-W 090;RP64305
- CHEMBL305660
- TQD7Q784P1
- 4-(4-(benzhydryloxy)piperidin-1-yl)-1-(4-(tert-butyl)phenyl)butan-1-one
- RP64305
- NCGC00164603-01
- Evastel
- Ebastinum [Latin]
- Ebastina [Spanish]
- Ebastinum
- Estivan
- Bastel
- CAS-90729-43-4
- UNII-TQD7Q784P1
- Ebastine [USAN:INN:BAN]
- 4-(4-(benzhydryloxy)piperidin-1-yl)-1-(4-tert-butylphenyl)butan-1-one
- 4-[4-(Benzhydryloxy)piperidin-1-yl]-1-(4-tert-butylphenyl)butan-1-one
- 4-Diphenylmethoxy-1-(3-(4-tert-butylbenzoyl)propyl)piperidine
- No-Sedat
- Kestine (TN)
- MFCD00865661
- 4'-tert-Butyl-4-(4-(diphenylmethoxy)piperidino)butyrophenone
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