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BUTENAFINE

SynDRA canonical compound SYN0002981 — structure-anchored drug synonym record

All known targets

• ACHE
• ADRA2A
• CYP2D6
• Candi ERG1
• ERG1
• Pgrmc1
• SIGMAR1
• SLC6A2
• SLC6A4
• SQLE
• fabI

Mechanisms of action (all sources)

• fungal squalene epoxidase inhibitor
• Candi ERG1 MODULATOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• ADORA1
• NPY2R
• MMP9
• MMP1
• MLNR
• MC5R
• MC4R
• MC3R
• MAPK3
• MAPK14
• MAPK1
• MAOA
• LMNA
• LCK
• HTR6
• HTR3A
• HTR2C
• HTR2B
• HTR2A
• HTR1A
• HRH3
• HRH2
• HRH1
• HMGCR
• HDAC6
• NPY1R
• NR1I2
• ADORA2A
• NR3C1
• USP1
• TDP1
• TBXAS1
• TBXA2R
• TACR2
• TACR1
• SLC6A3
• SLC29A1
• SAMHD1
• PTPRC
• PTGS2

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• CP2CJ
• CP2D6
• GPR32

Drug classes

• Anti-Infective Agents
• Antifungal Agents
• Benzylamine Antifungal

ATC classes

• D01A · ANTIFUNGALS FOR TOPICAL USE

Cross-references

• PubChem CID: 2484
• ChEMBL: CHEMBL990
• DrugBank: DB01091
• ChEBI: CHEBI:3238
• KEGG: D01093
• RxNorm: 47461
• Wikipedia: Butenafine
• TTD: D0B4DC
• LINCS BRD: BRD-K90630139

Synonyms

• BUTENAFINE HYDROCHLORIDE
• LOTRIMIN ULTRA
• MENTAX
• MENTAX-TC
• Mentax
• KP 363
• butenafine hydrochloride
• butenafine HCl
• Butenafina
• Butenafinum
• Butenafine HCL
• Butenafine [INN]
• Butenafine hydrochloride
• KP-363
• Butenafina [INN-Spanish]
• Butenafine (INN)
• Butenafinum [INN-Latin]
• Butop (TN)
• Mentax (TN)
• N-p-tert-Butylbenzyl-N-methyl-1-naphthalenemethylamine
• N-(p-tert-Butylbenzyl)-N-methyl-1-naphthalenemethylamine
• 4-tert-butylbenzyl(methyl)(1-naphthalenemethyl)amine
• CHEBI:3238
• DTXCID5020657
• (4-tert-Butyl-benzyl)-methyl-naphthalen-1-ylmethyl-amine
• RefChem:54581
• D01AE23
• NCGC00159511-02
• CAS-101828-21-1
• MFCD00917064
• C23H27N
• Butenafine [INN:BAN]
• SR-05000001448
• UNII-91Y494NL0X
• Spectrum_001553
• BUTENAFINE [MI]
• SpecPlus_000920
• BUTENAFINE [VANDF]