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NALMEFENE

SynDRA canonical compound SYN0002886 — structure-anchored drug synonym record

All known targets

• OPRD1
• OPRK1
• OPRM1
• Oprd1
• Oprm1

Mechanisms of action (all sources)

• Opioid receptor antagonist
• OPRM1 ANTAGONIST
• Mu opioid receptor antagonist
• OPRD1 ANTAGONIST
• Delta opioid receptor antagonist
• OPRK1 PARTIAL AGONIST
• Kappa opioid receptor partial agonist
• OPRD1 PARTIAL AGONIST
• OPRK1 ANTAGONIST

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• ADORA1
• MLNR
• HDAC6
• HRH1
• HRH2
• HRH3
• HTR1A
• HTR2A
• HTR2B
• HTR2C
• HTR3A
• KCNH2
• MAOA
• MBNL1
• MC3R
• NPY1R
• ADORA2A
• NR1I2
• NR3C1
• PDE3A
• PDE4D
• PGR
• PTGS2
• SAMHD1
• SLC29A1
• SLC6A2
• SLC6A3
• SLC6A4
• TARDBP
• TBXA2R
• GMNN
• GLS
• GHSR
• EDNRA
• ADORA3
• ADRA1A
• ADRA2A
• ADRA2B
• ADRA2C
• ADRB1

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• CP2D6
• ESR1

Drug classes

• Opioid Antagonists
• Central Nervous System Agents
• Narcotic Antagonists
• Peripheral Nervous System Agents
• Sensory System Agents
• Opioid Antagonist

ATC classes

• N07B · DRUGS USED IN ADDICTIVE DISORDERS

Cross-references

• PubChem CID: 5284594
• ChEMBL: CHEMBL982
• DrugBank: DB06230
• ChEBI: CHEBI:7457
• KEGG: D05111
• RxNorm: 31479
• Wikipedia: Nalmefene
• TTD: D02QLQ
• LINCS BRD: BRD-A72767275

Synonyms

• NALMEFENE HYDROCHLORIDE
• OPVEE
• Opvee
• REVEX
• ZURNAI (AUTOINJECTOR)
• Zurnai
• nalmefene hydrochloride dihydrate
• selincro
• nalmetrene
• 6-desoxy-6-methylenenaltrexone
• nalmefene hydrochloride
• nalmefene HCl
• ORF-11676
• nalmefene hydrochloride hydrate
• Nalmefeno
• Nalmetrene
• JF-1
• JKB-121
• ORF-1167
• SRD-174
• SRD174
• Selincro
• Pruritis treatment, Serentis
• Alcofene
• Arthene
• Cervene
• Cessal
• Incystene
• Nalmefenum
• Nalmetreno
• Nalmetrenum
• Revex
• Soberal
• NIH-10365
• Nalmefeno [INN-Spanish]
• Nalmefenum [INN-Latin]
• Nalmetreno [INN-Spanish]
• Nalmetrenum [INN-Latin]