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HYDROCORTISONE HEMISUCCINATE ANHYDROUS
SynDRA canonical compound SYN0002864 — structure-anchored drug synonym record
| Clinical phase | Phase 2/Phase 3 |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | NR3C1 |
|---|
| Mechanism of action | Glucocorticoid receptor agonist |
|---|
All known targets
- NR3C1
- Nr3c1
- ANXA1
- NOS2
- NR3C2
- ESRRA
- ESRRB
- ESRRG
- SERPINA6
- KCNA1
- SHBG
- SLC47A1
Mechanisms of action (all sources)
- NR3C1 AGONIST
- NR3C1 MODULATOR
- Corticosteroid agonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- RAPGEF3
- OPRM1
- PDE3A
- PDE4A
- PGR
- PMP22
- POLI
- PTGS1
- SLC6A2
- MAOA
- SLC6A3
- SLC6A4
- SLCO1B1
- SLCO1B3
- SMAD3
- SMN1
- TBXA2R
- NFE2L2
- KDR
- ADORA3
- EHMT2
- ADRA1A
- ADRA2A
- AR
- CBX1
- CHRM1
- CHRM2
- DRD1
- ESR1
- KCNH2
- F2
- HDAC6
- HIF1A
- HRH3
- HTR1A
- HTR2B
- IDH1
- TDP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ADA17
- ANDR
- CFTR
- DRD3
- ITA4
- NSD2
- STAT1
Drug classes
- Corticosteroid Hormone Receptor Agonists
- Corticosteroid
- Anti-Inflammatory Agents
- Dermatologic Agents
ATC classes
- S01B · ANTIINFLAMMATORY AGENTS
- A07E · INTESTINAL ANTIINFLAMMATORY AGENTS
- S01C · ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
- D07A · CORTICOSTEROIDS, PLAIN
- D07X · CORTICOSTEROIDS, OTHER COMBINATIONS
- A01A · STOMATOLOGICAL PREPARATIONS
- R01A · DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
- C05A · AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
- H02A · CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
- S02B · CORTICOSTEROIDS
- CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
- CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Cross-references
Synonyms
- A-HYDROCORT
- ACETASOL HC
- ACETIC ACID W/ HYDROCORTISONE
- ACHROMYCIN
- ACTICORT
- AEROSEB-HC
- ALA-CORT
- ALA-SCALP
- ALKINDI SPRINKLE
- ALPHADERM
- ANUSOL HC
- Ala-Cort
- hydrocortisone succinate
- hydrocortisone sodium succinate
- hydrocortisone hemisuccinate
- Oristar hcshs
- NSC-7576
- hydrocortisone
- Hydrocortisone Succinate
- Cortisol succinate
- Hydrocortisone hydrogen succinate
- ORISTAR HCSHS
- Hydroxycortisone succinate
- IHV1VP592V
- CHEBI:31677
- cortisol-21-(hydrogen succinate)
- RefChem:789013
- Hydrocortisone 21-hemisuccinate
- Cortisol 21-hemisuccinate
- MLS000028530
- MLS001146928
- Hydrocortisone succinate [JAN]
- Solucortef
- Arcocort
- Intracort
- Oralsone
- Corlan
- MFCD00046256
- Emi-Corlin
Reported adverse events
- Ototoxicity
- Cushingoid
- Sodium retention
- Hypertension
- Exophthalmos
- Tendon rupture
- Fluid retention
- Vertigo
- Perioral dermatitis
- Epidural lipomatosis
- Central serous chorioretinopathy
- Hypertrichosis
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