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TERIFLUNOMIDE
SynDRA canonical compound SYN0002822 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CYP1A2 | CYP2C8 | DHODH | MMP2 | MMP9 |
|---|
| Mechanism of action | dihydroorotate dehydrogenase inhibitor |
|---|
| Indication | multiple sclerosis |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- DHODH
- CYP1A2
- CYP2C8
- DHFR
- Dhodh
- MMP2
- MMP9
- dhod
- AHR
- CYP2C19
- JAK3
- PTK2B
Mechanisms of action (all sources)
- DHODH INHIBITOR
- Dihydroorotate dehydrogenase inhibitor
- PDGFR inhibitor
- PDGFR tyrosine kinase receptor inhibitor
- Malaria DHOdehase INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- MAOA
- ADORA1
- OPRD1
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- KCNH2
- MC3R
- MLNR
- NR1I2
- NR3C1
- OPRM1
- ADORA2A
- PDE3A
- PDE4D
- PGR
- PPARG
- PTGS2
- RORC
- SCN5A
- SLC29A1
- SLC6A2
- SLC6A3
- HTR1A
- HRH3
- HRH1
- HDAC6
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- ADRB1
- ADRB2
- AGTR1
- AVPR1A
- CCKAR
- CHRM1
- CHRM2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Immunologic Factors
- Immunosuppressive Agents
- Peripheral Nervous System Agents
- Sensory System Agents
- Dihydroorotate Dehydrogenase Inhibitors
- Pyrimidine Synthesis Inhibitor
- Enzyme Inhibitors
ATC classes
- L04A · IMMUNOSUPPRESSANTS
Cross-references
Synonyms
- AUBAGIO
- Aubagio
- HMR1726
- flucyamide
- aubagio
- Teriflunomida
- A77 1726
- HMR-1726
- Teriflunomide accord
- Teriflunomide mylan
- Leflunomide related compound b
- Leflunomide related compound b rs
- Flucyamide
- A77-1726
- HMR 1726
- A-771726
- SU 20
- A771726
- A 77-1726
- (E/Z)-Teriflunomide
- CHEBI:68540
- Teriflunomide(Random Configuration)
- 1C058IKG3B
- Teriflunomide (USAN)
- Teriflunomide [INN]
- TERIFLUNOMIDE [USAN]
- MFCD00910058
- RS-61980
- Teriflunomide [USAN:INN]
- teriflunomida
- teriflunomidum
- UNII-1C058IKG3B
- Malononitrilamide
- A 1726
- A26
- Aubagio (TN)
- SU-0020
Reported adverse events
- Hepatotoxicity
- Teratogenicity
- Dizziness
- Pruritus
- Rhinitis
- Tenosynovitis
- Alopecia
- Infection
- Nausea
- Pancreatitis
- Arthralgia
- Headache
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