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DISULFIRAM
SynDRA canonical compound SYN0002800 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ALDH2 |
|---|
| Mechanism of action | Aldehyde dehydrogenase inhibitor |
|---|
| Indication | abstinence from alcohol |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- ALDH2
- ADORA3
- MGLL
- HTR2B
- HTR6
- Htr1b
- KDM5A
- LOX
- LOXL2
- LOXL3
- LOXL4
- MAOA
Mechanisms of action (all sources)
- TRPV agonist
- DNMT inhibitor
- Aldehyde dehydrogenase inhibitor
- ALDH2 INHIBITOR
- ALDH3A2 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB11
- ADRB2
- ESR1
- PHGDH
- CASP1
- KCNH2
- THPO
- USP1
- PDE5A
- PDE3A
- OPRD1
- NR3C1
- NPY2R
- NPY1R
- VDR
- NPSR1
- NFKB1
- NFE2L2
- MTOR
- MPHOSPH8
- MMP9
- MMP1
- MDM2
- MC5R
- MC4R
- MC3R
- MBNL1
- MAPT
- MAPK14
- MAPK1
- LMNA
- LCK
- KMT2A
- KDR
- KDM4A
- PGR
- PKM
- TDP1
- PLK1
- TP53
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- NNMT
- NTMT1
- NTM1A
- NSD2
- NR1I2
- NPR2
- NPR1
- NOD1
- NLRP1
- PEBB
- NF2L2
- MDR1
- LRC26
- LOX12
- KSYK
- KCMB1
- JUN
- PE2R2
- PHOP1
- A4
- RUNX1
- TOR1A
- TAAR1
- SYK
- STK33
- SMCA2
- SMAD2
- SARM1
- RARA
- PIP4K2A
- PRMT1
- PRGR
- PPARG
- PPARD
- PNMT
- PLIN5
- PLIN1
- ITPK1
- IP6K1
Drug classes
- Acetyl Aldehyde Dehydrogenase Inhibitors
- Acetaldehyde Dehydrogenase Inhibitors
- Alcohol Deterrents
- Central Nervous System Agents
- Enzyme Inhibitors
- Aldehyde Dehydrogenase Inhibitor
ATC classes
- P03A · ECTOPARASITICIDES, INCL. SCABICIDES
- N07B · DRUGS USED IN ADDICTIVE DISORDERS
Cross-references
Synonyms
- ANTABUSE
- Antabuse
- tetraethylthiram disulfide
- Disulfirame
- NSC-25953
- ORA-102
- ORA102
- Esperal
- Abstenisil
- Abstinil
- Abstinyl
- Alcophobin
- Antabus
- Antadix
- Antaenyl
- Antaethan
- Antaethyl
- Antaetil
- Antalcol
- Antetan
- Antethyl
- Antetil
- Anteyl
- Anthethyl
- Antiaethan
- Anticol
- Antietanol
- Antiethanol
- Antietil
- Antikol
- Antivitium
- Aversan
- Averzan
- Bonibal
- Contralin
- Contrapot
- Cronetal
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