← SynDRA
BOSENTAN
SynDRA canonical compound SYN0002782 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | EDNRB |
|---|
| Mechanism of action | Endothelin receptor antagonist |
|---|
| Indication | pulmonary arterial hypertension (PAH) |
|---|
| Disease area | pulmonary |
|---|
All known targets
- EDNRB
- EDNRA
- ABCB1
- ABCB11
- Abcb11
- CYP2C19
- CYP3A4
- Ednra
- Ednrb
- NR1I2
Mechanisms of action (all sources)
- Endothelin receptor antagonist
- EDNRB ANTAGONIST
- Endothelin receptor, ET-A/ET-B antagonist
- EDNRA ANTAGONIST
- EDNRA MODULATOR
- EDNRB MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NR1I3
- NR1H3
- MC3R
- NR1H4
- NR1H2
- NPY2R
- NPY1R
- MLNR
- MC4R
- ABCC2
- NR3C1
- KCNH2
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- MAOA
- NTSR1
- HRH1
- RARB
- TBXA2R
- SLC6A4
- SLC6A3
- SLC6A2
- SLC29A1
- SAMHD1
- RARG
- RARA
- OPRD1
- PTGS2
- PPARA
- PGR
- PDE4D
- PDE3A
- OPRM1
- OPRK1
- HRH2
- HDAC6
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Endothelin Receptor Antagonists
- Endothelin Receptor Antagonist
- Antihypertensive Agents
- Cardiovascular Agents
- Cytochrome P450 2C9 Inducers
- Cytochrome P450 3A Inducers
ATC classes
- C02K · OTHER ANTIHYPERTENSIVES
Cross-references
Synonyms
- TRACLEER
- Tracleer
- bosentan hydrate
- bosentan monohydrate
- stayveer
- actelion
- tracleer
- bosentan anhydrous
- Bosentan (as monohydrate)
- Bosentan hydrate
- Bosentan monohydrate
- Anhydrous bosentan
- Bosentan anhydrous
- RO-47-0203/029
- RO-47-0203-029
- RO-470203029
- Stayveer
- Actelion
- Bosentanum
- Bosentan (INN)
- KS-5062
- Ro-47-0203
- Tracleer (TN)
- Bosentan [USAN:INN:BAN]
- Ro-47-0203/039
- Ro-47-0203/029
- P-tert-Butyl-N-[6-(2-hydroxyethoxy)
- CHEMBL957
- XUL93R30K2
- CHEBI:51450
- 147536-97-8 (free)
- NCGC00167440-01
- BOSENTAN [INN]
- bosentanum
- CAS-147536-97-8
- SR-05000001532
- Ro-470203029
Reported adverse events
- Hepatotoxicity
- Flushing
- Headache
- Palpitations
- Autoimmune hepatitis
- Rash
- Hypersensitivity
- Nasal congestion
- Syncope
- Thrombocytopenia
- Hypotension
- Neutropenia
Look up BOSENTAN in the interactive SynDRA portal →