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SPIROXATRINE
SynDRA canonical compound SYN0002768 — structure-anchored drug synonym record
| Clinical phase | Preclinical |
|---|
| Primary target(s) | HTR1A |
|---|
| Mechanism of action | Serotonin receptor antagonist |
|---|
All known targets
- HTR1A
- ADRA1B
- ADRA2B
- ADRA2C
- HTR2B
- ADRA1A
- ADRA1D
- ADRA2A
Mechanisms of action (all sources)
- Serotonin receptor antagonist
- HTR1A FULL AGONIST
- HTR2B ANTAGONIST
- ADRA1A ANTAGONIST
- ADRA1B ANTAGONIST
- ADRA1D ANTAGONIST
- ADRA2A ANTAGONIST
- ADRA2B ANTAGONIST
- ADRA2C ANTAGONIST
- HTR1A AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- DRD2
- OPRK1
- DRD4
- TMEM97
- HTR5A
- HTR7
- DRD3
- HTR2A
- SLC6A2
- NR1I2
- OPRM1
- OPRL1
- NEIL1
- MBD4
- MPHOSPH8
- LMNA
- KCNH2
- HTR3A
- NEIL2
- ADGRF1
- NTHL1
- OGG1
- OPRD1
- POLI
- S1PR1
- SLC6A3
- SLC6A4
- SMUG1
- TDG
- TSPO
- HTR2C
- HTR1D
- HTR1E
- CX3CR1
- ADRB2
- AGTR1
- APLNR
- ARSA
- ATAD5
- BLM
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT1A
- 5HT2A
- 5HT2B
- ADA1A
- ADA1B
- ADA1D
- ADA2B
- ADA2C
- CP2C9
- CP2CJ
- CP2D6
- CP3A4
- CP3A7
- TADA2A
Drug classes
Cross-references
Synonyms
- Espiroxatrina
- NSC-665322
- R-5188
- spiroxamide
- Spiroxatrinum
- SPIROXAMIDE
- DR0QR50ALL
- NSC 665322
- DTXCID1025198
- RefChem:184962
- Spiroxatrine (R 5188)
- Spiroxatrine [INN]
- NSC665322
- NCGC00015908-05
- Spiroxatrinum [INN-Latin]
- Espiroxatrina [INN-Spanish]
- CAS-1054-88-2
- SR-01000075579
- UNII-DR0QR50ALL
- Biomol-NT_000104
- GTPL53
- Lopac0_001142
- BPBio1_001395
- orb1704044
- SCHEMBL1255303
- SCHEMBL23326247
- CHEBI:91845
- HMS2089G17
- HMS3263F05
- HMS3266D15
- HMS3411K18
- HMS3675K18
- Tox21_110260
- Tox21_501142
- BDBM50020192
- AKOS024458589
- Tox21_110260_1
- CCG-205216
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