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CYCLOTHIAZIDE
SynDRA canonical compound SYN0002758 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | CA2 |
|---|
| Mechanism of action | Glutamate receptor modulator |
|---|
| Indication | hypertension |
|---|
| Disease area | cardiology |
|---|
All known targets
- SLC12A3
- CA2
- GRIA1
- GRIA2
- GRIA3
- GRIA4
- Gria1
- Gria2
- Gria3
- Gria4
Mechanisms of action (all sources)
- Glutamate receptor modulator
- SLC12A3 INHIBITOR
- Thiazide-sensitive sodium-chloride cotransporter inhibitor
- GRIA1 POSITIVE ALLOSTERIC MODULATOR
- GRIA2 POSITIVE ALLOSTERIC MODULATOR
- GRIA3 POSITIVE ALLOSTERIC MODULATOR
- GRIA4 POSITIVE ALLOSTERIC MODULATOR
- CA2 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- PGR
- KDR
- KMT2A
- LMNA
- MAOA
- OPRM1
- PDE3A
- PDE4A
- PIN1
- ADORA3
- PTGS1
- RECQL
- RGS4
- SLC6A2
- SLC6A3
- SLC6A4
- TBXA2R
- KCNH2
- HTR2B
- HTR1A
- HRH3
- ADRA1A
- ADRA2A
- APEX1
- AR
- ARSA
- BLM
- CBX1
- CHRM1
- CHRM2
- DRD1
- EHMT2
- ESR1
- F2
- GMNN
- HDAC6
- THRB
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Antihypertensive Agents
- Cardiovascular Agents
- Diuretics
- Natriuretic Agents
ATC classes
- C03A · LOW-CEILING DIURETICS, THIAZIDES
Cross-references
Synonyms
- ANHYDRON
- FLUIDIL
- ciclotiazide
- Ciclotiazida
- 35483
- NSC-758431
- Anhydron
- Fluidil
- Aquirel
- Ciclotiazide
- Cyclothiazidum
- Doburil
- Renazide
- Valmiran
- Ciclotiazide [DCIT]
- C 9847
- MDi 193
- Anhydron (TN)
- Ciclotiazida [INN-Spanish]
- Cyclothiazidum [INN-Latin]
- Lilly 35,483
- Cyclothiazide [USAN:INN:BAN]
- Cyclothiazide (JAN/USAN/INN)
- NSC 758431
- P71U09G5BW
- DTXCID302871
- CHEBI:31448
- RefChem:54917
- C03AA09
- NCGC00015288-06
- CAS-2259-96-3
- HSDB 3310
- SR-01000075796
- EINECS 218-859-7
- BRN 0722843
- UNII-P71U09G5BW
- Cyclothiazide [USAN:USP:INN:BAN]
- Lilly 35483; MDi 193; Renazide; Valmiran
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