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ENTACAPONE
SynDRA canonical compound SYN0002755 — structure-anchored drug synonym record
| Clinical phase | Launched |
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| Approval status | Approved · Rx/OTC |
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| Primary target(s) | COMT |
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| Mechanism of action | catechol O methyltransferase inhibitor |
|---|
| Indication | Parkinson's Disease |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
Mechanisms of action (all sources)
- COMT INHIBITOR
- Catechol O-methyltransferase inhibitor
- catechol O methyltransferase inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCC4
- UGT1A9
- CYP2C9
- ABCB11
- NIPSNAP3A
- KAT2A
- KMT2A
- KYAT3
- LMNA
- MAPK1
- PDXK
- HDAC6
- POLK
- SAMHD1
- TRIM24
- UGT1A8
- UGT2B15
- HIBCH
- GSK3B
- ABCC3
- GLS
- GCDH
- FGFR2
- F2
- EHMT2
- CSNK1D
- CDK2
- BRPF1
- BRD4
- AURKA
- AKR1B10
- ADI1
- ABL1
- VDR
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ALAT2
- ANDR
- CP2C9
- CP3A7
- GAMT
- GNMT
- HDAC9
- HIF1A
- HNMT
- HSPB1
- KSYK
- NF2L2
- NNMT
- PNMT
- SYK
- TP53
Drug classes
- Anti-Dyskinesia Agents
- Antiparkinson Agents
- Catechol O-Methyltransferase Inhibitors
- Central Nervous System Agents
- Enzyme Inhibitors
- Catechol-O-Methyltransferase Inhibitor
ATC classes
- N04B · DOPAMINERGIC AGENTS
Cross-references
Synonyms
- CARBIDOPA, LEVODOPA AND ENTACAPONE
- COMTAN
- Comtan
- STALEVO 100
- STALEVO 125
- STALEVO 150
- STALEVO 200
- STALEVO 50
- STALEVO 75
- entacom
- comtess
- Entacapona
- Entacapone orion
- Entacapone teva
- OR-611
- Comtess
- Entacapone component of corbilta
- Entacapone component of levodopa/carbidopa/ orion
- Entacapone component of stalevo
- Entacaponum
- Novartis brand of entacapone
- Orion brand of entacapone
- KB475572
- COM-998
- Comtan (TN)
- Entacapona [INN-Spanish]
- Entacapone [USAN:INN]
- Entacaponum [INN-Latin]
- Stalevo (TN)
- Entacapone (JAN/USAN/INN)
- LEVODOPA/CARBIDOPA/ENTACAPONE ORION COMPONENT ENTACAPONE
- OR 611
- entacapone (usp monograph)
- CORBILTA COMPONENT ENTACAPONE
- entacapone (ep monograph)
- STALEVO COMPONENT ENTACAPONE
- entacapone (usp-rs)
Reported adverse events
- Agitation
- Constipation
- Fatigue
- Nausea
- Anxiety
- Asthenia
- Dizziness
- Dyspepsia
- Flatulence
- Gastritis
- Hyperkinesia
- Hypokinesia
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