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CAPSAICIN
SynDRA canonical compound SYN0002752 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CFTR | ENOX2 | TRPV1 |
|---|
| Mechanism of action | TRPV agonist |
|---|
| Indication | muscle pain | rheumatoid arthritis |
|---|
| Disease area | neurology/psychiatry | rheumatology |
|---|
All known targets
- TRPV1
- ALOX5
- CFTR
- CYP1A2
- ENOX2
- KCNA1
- KDM1A
- Kcna1
- Kcna2
- Kcna7
- MT-ND1
- PTGS1
Mechanisms of action (all sources)
- TRPV1 OPENER
- Vanilloid receptor opener
- TRPV agonist
- TRPV1 AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB11
- ESR2
- DRD3
- ESR1
- PTGS2
- NR1I2
- MMP9
- MMP1
- MLNR
- MC5R
- LMNA
- MC3R
- MAPT
- MAPK3
- MAPK14
- MAPK1
- MAOA
- MC4R
- KCNH2
- LCK
- NPY1R
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HSD17B10
- HRH3
- HRH2
- HRH1
- HMGCR
- NFE2L2
- NPY2R
- GLS
- NR3C1
- TTR
- TRPV6
- TDP1
- TBXAS1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- NF2L2
- SMAD3
- SMAD2
- RPGF4
- RAPGEF4
- PRGR
- PAFA
- NSD2
- KSYK
- CP19A
- GPR151
- ESRRA
- CP3A4
- CP2D6
- CP2CJ
- CP2C9
- CP1A2
- SYK
Drug classes
- Antipruritics
- Dermatologic Agents
- Peripheral Nervous System Agents
- Sensory System Agents
ATC classes
- N01B · ANESTHETICS, LOCAL
- M02A · TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Cross-references
Synonyms
- Capzasin-HP
- Equi-Block Original
- QUTENZA
- Qutenza
- Red Hot
- Satogesic Hot
- Zostrix
- capsaicine
- qutenza
- NGX 4010
- Capsaicine
- Capsaicina
- Ausanil
- Axsain
- Capzasin-hp
- Cntx-4975
- Dolenon
- Mioton
- NGX-1998
- Ovocap
- Ratden pe 40
- Togarashi orenji
- Trans-capsaicin
- ALGRX-4975
- FEMA NO. 3404
- NGX-4010
- NSC-56353
- Zacin
- Zostrix hp
- Capsaicin (transdermal patch formulation, neuropathic pain)
- (E)-Capsaicin
- CAPSAICINE
- Styptysat
- Isodecenoic acid vanillylamide
- E-CAPSAICIN
- trans-Capsaicin
- trans-8-Methyl-N-vanillyl-6-nonenamide
- FEMA No. 3404
Reported adverse events
- Bleeding
- GI bleed
- Ulceration
- Elderly
- Hypertension
- Nausea
- Stevens-Johnson syndrome
- Perforation
- Application site reaction
- Hepatotoxicity
- Infection
- Sinusitis
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