← SynDRA
AMILORIDE
SynDRA canonical compound SYN0002720 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SCNN1G |
|---|
| Mechanism of action | Sodium channel blocker |
|---|
| Indication | congestive heart failure | hypertension |
|---|
| Disease area | cardiology |
|---|
All known targets
- SCNN1G
- SCNN1B
- SCNN1A
- ASIC1
- ASIC2
- ASIC3
- PLAU
- PKD2L1
- TRPC7
- SLC9A5
- SLC9A1
- TRPV2
Mechanisms of action (all sources)
- Sodium channel blocker
- SCNN1A BLOCKER
- Amiloride-sensitive sodium channel, ENaC blocker
- SCNN1B BLOCKER
- SCNN1G BLOCKER
- ASIC1 MODULATOR
- ASIC2 MODULATOR
- ASIC3 MODULATOR
- SCNN1A MODULATOR
- SCNN1B MODULATOR
- SCNN1G MODULATOR
- GABRA6 ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NR1I2
- ADRA1A
- SCN5A
- OPRM1
- FTO
- HTR2B
- ABCC2
- MC3R
- LMNA
- MAPK1
- MAPK14
- MAPK3
- MBNL1
- MC5R
- MC4R
- KLKB1
- MLNR
- MMP1
- MMP9
- MTOR
- NFE2L2
- NPY1R
- LCK
- HTT
- KDM4E
- HRH3
- GMNN
- HDAC6
- HMGCR
- HPGD
- HRH1
- HRH2
- HSD17B10
- KCNH2
- HTR1A
- HTR2A
- HTR2C
- HTR3A
- HTR6
- HTR7
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACES
- PLK1
- UBE2M
- TP53
- SYK
- SL9A5
- SC5A7
- PTBP1
- PK2L1
- AHR
- NTM1A
- NF2L2
- KSYK
- KPCD1
- HDAC9
- CP1A2
- ULA1
Drug classes
- Potassium-sparing Diuretic
- Acid Sensing Ion Channel Blockers
- Diuretics
- Epithelial Sodium Channel Blockers
- Membrane Transport Modulators
- Natriuretic Agents
- Sodium Channel Blockers
ATC classes
- C03D · ALDOSTERONE ANTAGONISTS AND OTHER POTASSIUM-SPARING AGENTS
Cross-references
Synonyms
- AMILORIDE HYDROCHLORIDE
- AMILORIDE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE
- HYDRO-RIDE
- MIDAMOR
- MODURETIC 5-50
- amiloride hydrochloride
- amiloride hydrochloride anhydrous
- amiloride hydrochloride dihydrate
- amiloride HCl
- Amilorida
- Amiclaran
- Hydro-ride
- Amiloridum
- Amipramidin
- Amipramizid
- Amipramizide
- Amiprazidine
- Amyloride
- Guanamprazin
- Guanamprazine
- Midamor
- Amiloride HCL
- Amiloride hydrochloride hydrate
- Amiclaran (TN)
- Amikal (Hydrochloride dihydrate)
- Amilorida [INN-Spanish]
- Amiloride (INN)
- Amiloride [INN:BAN]
- Amiloridum [INN-Latin]
- Biduret (TN)
- Midamor (Hydrochloride dihydrate)
- MK-870 (Hydrochloride dihydrate)
- AMILORIDE (SEE ALSO: AMILORIDE HCL (2016-88-8))
- N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide
- N-Amidino-3,5-diamino-6-chlorpyrazincarboxamid
- 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide
- Amiloride (Na-Ca chanel blocker)
- 7DZO8EB0Z3
Reported adverse events
- Hyperkalemia
- Nausea
- Nasal congestion
- Nervousness
- Thirst
- Abdominal pain
- Angina pectoris
- Constipation
- Depression
- Dizziness
- Flatulence
- Insomnia
Look up AMILORIDE in the interactive SynDRA portal →