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PRAMIPEXOLE
SynDRA canonical compound SYN0002707 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | DRD3 |
|---|
| Mechanism of action | Dopamine receptor agonist |
|---|
| Indication | Parkinson's Disease |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- DRD2
- DRD3
- DRD4
- ADRA2A
- ADRA2C
- HTR2A
- HTR1D
- ADRA2B
- HTR1B
- HTR1A
- HRH4
- HTR2C
Mechanisms of action (all sources)
- Dopamine receptor agonist
- DRD2 AGONIST
- D2-like dopamine receptor agonist
- DRD3 AGONIST
- DRD4 AGONIST
- DRD3 MODULATOR
- DRD2 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- SIGMAR1
- ADGRF1
- NPY1R
- OPRK1
- OPRD1
- OGG1
- NTHL1
- NR3C1
- NR1I2
- NEIL1
- PDE3A
- MUTYH
- MPG
- MLNR
- MC4R
- MC3R
- MBD4
- MAOA
- OPRM1
- PDE4D
- ADORA1
- SLC6A3
- TMEM97
- TDP1
- TDG
- TBXA2R
- SNCA
- SLC6A4
- SLC6A2
- PGR
- SLC47A2
- SLC29A1
- SAMHD1
- S1PR1
- PTGS2
- POLI
- KCNH2
- HTR6
- HTR5A
- HTR3A
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- ACES
- CP1A2
- CP2CJ
- CP2D6
- KSYK
- SYK
Drug classes
- Dopamine Agonists
- Anti-Dyskinesia Agents
- Antioxidants
- Antiparkinson Agents
- Central Nervous System Agents
- Dopamine Agents
- Neurotransmitter Agents
- Protective Agents
- Nonergot Dopamine Agonist
ATC classes
- N04B · DOPAMINERGIC AGENTS
Cross-references
Synonyms
- MIRAPEX
- MIRAPEX ER
- Mirapex
- PRAMIPEXOLE DIHYDROCHLORIDE
- pramipexole hydrochloride
- pramipexole hydrochloride hydrate
- sifrol
- oprymea
- (S)-Pramipexole
- mirapexin
- pramipexole dihydrochloride
- pramipexole dihydrochloride monohydrate
- pramipexole HCl
- pramipexol dihydrobromide
- Pramipexol
- Ctc-501
- NSC-760426
- SUD-919CL2Y
- SUD919CL2Y
- U-98528E
- Neliprax
- Pipexus
- Pramipexolum
- Mirapex (TN)
- Mirapexin (TN)
- Pramipexole [USAN:INN]
- SND-919
- Sifrol(TN)
- Pramipexole (USAN/INN)
- (-)-Pramipexole
- 111GE001
- 2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole
- 2-amino-6-propylaminotetrahydrobenzothiazole
- CTC-501
- SUD 919CL2Y
- NSC 760426
- (-) Pramipexole
- mirapex
Reported adverse events
- Nausea
- Somnolence
- Hypotension
- Dystonia
- Hallucination
- Dyskinesia
- Insomnia
- Akathisia
- Amnesia
- Asthenia
- Bursitis
- Constipation
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