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RITONAVIR
SynDRA canonical compound SYN0002693 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CYP3A5 |
|---|
| Mechanism of action | HIV protease inhibitor |
|---|
| Indication | human immunodeficiency virus (HIV-1) |
|---|
| Disease area | infectious disease |
|---|
All known targets
- CYP3A4
- CYP3A5
- CYP3A7
- CYP2C9
- CYP2D6
- CYP3A43
- CYP1A2
- CYP2B6
- CYP2C19
- CYP2C8
- CYP2E1
- UGT1A1
Mechanisms of action (all sources)
- protease inhibitor
- CYP3A4 INHIBITOR
- Cytochrome P450 3A inhibitor
- CYP3A5 INHIBITOR
- CYP3A43 INHIBITOR
- CYP3A7 INHIBITOR
- HIV PR INHIBITOR
- HCV NS3 MODULATOR
- pol INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB11
- SLCO1B3
- PGR
- HTR2B
- KCNH2
- SLCO1B1
- ADRA1A
- SLCO2B1
- TACR1
- TBXA2R
- HTR7
- MC3R
- MAPT
- MAPK3
- MAPK14
- MAPK1
- MAOA
- MC4R
- LCK
- MC5R
- KDR
- HTR2C
- KAT2A
- HTR6
- HTR3A
- MMP1
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- GLS
- MLNR
- NPY2R
- MMP9
- NPSR1
- VDR
- TDP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ATXN2
- CAC1H
- CP2C9
- CP2CJ
- CP2D6
- ESRRA
- GCR
- KCMA1
- KCMB1
- KCMB2
- KCMB4
- LRC26
- PPARG
Drug classes
- HIV Protease Inhibitors
- Protease Inhibitor
- Cytochrome P450 2D6 Inhibitors
- Cytochrome P450 3A4 Inhibitors
- P-Glycoprotein Inhibitors
- Cytochrome P450 2C9 Inducers
- Cytochrome P450 2C19 Inducers
- Cytochrome P450 2B6 Inducers
- Breast Cancer Resistance Protein Inhibitors
- Cytochrome P450 3A Inhibitors
- UDP Glucuronosyltransferases Inducers
- Cytochrome P450 3A Inducers
ATC classes
- J05A · DIRECT ACTING ANTIVIRALS
Cross-references
Synonyms
- KALETRA
- LOPINAVIR AND RITONAVIR
- NORVIR
- Norvir
- PAXLOVID (COPACKAGED)
- TECHNIVIE
- VIEKIRA XR
- ABT538
- ABT-538
- norvir
- Empetus
- Ritomune
- Ritonavirum
- Ritovir
- Viekirax
- Viriton
- A-84538
- ABBOTT-84538
- NSC-693184
- Ritonavir component of kaletra
- Ritonavir component of paxlovid
- Ritonavir component of technivie
- Ritonavir component of viekirax
- Ritonavir component of xiannuoxin
- Ritonavir mylan
- Ritonavir related compounds mixture
- Ombitasvir + paritaprevir + ritonavir
- ABT-267/ABT-450/ritonavir
- ABT-267/ritonavir/ABT-450
- ABT-450/ABT-267/ritonavir
- ABT-450/r + NS5A
- ABT-450/r/ABT-267
- ABT-450/ritonavir/ABT-267
- HOLKIRA PAK
- OBV/PTV/r
- Ombitasvir/ABT 450/ritonavir
- Ombitasvir/ritonavir/ABT-450
Reported adverse events
- Pancreatitis
- Dysgeusia
- Rash
- Hepatotoxicity
- Toxic epidermal necrolysis
- Hypertension
- Stevens-Johnson syndrome
- Myalgia
- Nausea
- Vomiting
- Acne
- Arthralgia
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