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METYRAPONE
SynDRA canonical compound SYN0002669 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CYP11B1 |
|---|
| Mechanism of action | Cytochrome P450 inhibitor |
|---|
| Indication | adrenal diagnostic agent |
|---|
| Disease area | nephrology |
|---|
All known targets
- CYP11B1
- CYP11B2
- CYP3A4
- Cyp11b1
- HSD11B1
- NR3C2
Mechanisms of action (all sources)
- Cytochrome P450 inhibitor
- CYP11B1 INHIBITOR
- Cytochrome P450 11B1, mitochondrial inhibitor
- CYP11B2 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- LCK
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- KCNH2
- NPY2R
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HSD11B2
- HRH2
- HRH1
- HMGCR
- HDAC6
- NPY1R
- NR1I2
- GALC
- PTPRC
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SLC6A4
- SLC6A3
- SLC6A2
- SLC29A1
- SIGMAR1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Antimetabolites
- Enzyme Inhibitors
- Noxae
- Adrenal Steroid Synthesis Inhibitors
- Adrenal Steroid Synthesis Inhibitor
ATC classes
- V04C · OTHER DIAGNOSTIC AGENTS
Cross-references
Synonyms
- METOPIRONE
- Metopirone
- mepyrapone
- methapyrapone
- methbipyranone
- methopirapone
- methopyrapone
- methopyrinine
- methopyrone
- metopiron
- metopirone
- metopyrone
- metroprione
- metyrapon
- Metirapona
- NSC-25265
- Metopiron
- MYT
- Mepyrapone
- Metapirone
- Metapyron
- Methapyrapone
- Methbipyranone
- Methopirapone
- Methopyrapone
- Methopyrinine
- Methopyrone
- Metopyrone
- Metroprione
- Metyrapon
- Metyraponum
- Alliance Brand of Metyrapone
- Metyrapone Alliance Brand
- Metyrapone Novartis Brand
- Novartis Brand of Metyrapone
- Su-4885
- METOPIRONE (TN)
- Metirapona [INN-Spanish]
Reported adverse events
- Headache
- Hypotension
- Leukopenia
- Nausea
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