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MEVASTATIN
SynDRA canonical compound SYN0002626 — structure-anchored drug synonym record
| Clinical phase | Preclinical |
|---|
| Primary target(s) | HMGCR |
|---|
| Mechanism of action | HMGCR inhibitor |
|---|
All known targets
Mechanisms of action (all sources)
- HMGCR INHIBITOR
- HMGCR ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- DRD2
- ABCB11
- KRAS
- MMP9
- MMP1
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- KCNH2
- NFE2L2
- IDH1
- HTT
- HTR6
- HTR2C
- HTR2B
- HTR2A
- HRH2
- HRH1
- HDAC6
- GNAS
- MTOR
- NPSR1
- FYN
- NPY1R
- TDP1
- TBXAS1
- TACR2
- TACR1
- SMN1
- SMAD3
- SLC6A4
- SLC6A3
- SLC6A2
- SIGMAR1
- SAMHD1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- COMT
- SMCA2
- PNMT
- NSD2
- NR0B1
- NNMT
- KSYK
- JAK2
- IDHC
- HNMT
- HMDH
- GNMT
- GCR
- GAMT
- ESRRA
- CP19A
- SYK
Drug classes
- Anti-Bacterial Agents
- Anticholesteremic Agents
- Antifungal Agents
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cross-references
Synonyms
- Mevastatine
- Mevastatina
- Compactin
- CS-500
- CS500
- L-637312
- L637312
- ML-236B LACTONE
- ML236B LACTONE
- NSC-281245
- NSC-759322
- NSC281245
- compactin
- ML-236B
- Mevastatinum
- Mevastatinum [INN-Latin]
- Antibiotic ML 236B
- Mevastatin [INN]
- CS 500
- Compactin (penicillium)
- Mevastatine [INN-French]
- UNII-1UQM1K0W9X
- ML 236 B
- Mevastatina [INN-Spanish]
- CCRIS 4505
- 1UQM1K0W9X
- CHEMBL54440
- CHEBI:34848
- [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
- Mevastatin (Compactin)
- ML236B
- EC 700-442-0
- NSC 759322
- (1S,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-7-methyl-8-(2-((2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthyl (S)-2-methylbutyrate
- (1S,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (S)-2-methylbutanoate
- (S)-((1S,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl) 2-methylbutanoate
- Butanoic acid, 2-methyl-, (1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-
- SMR000336944
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