← SynDRA

TRYPTOPHAN

SynDRA canonical compound SYN0002619 — structure-anchored drug synonym record

All known targets

• CASR
• IDO1
• GPR139
• MPO
• SLC36A1
• WARS1
• WARS2

Mechanisms of action (all sources)

• serotonin receptor partial agonist
• IDO1 BINDER

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• CA5A
• CA2
• CA5B
• ABCC2
• HIF1A
• KDM4E
• KMT2A
• KYAT1
• LMNA
• MAPT
• MPHOSPH8
• PKM
• PLAA
• FEN1
• PMP22
• POLI
• SAMHD1
• SLC16A10
• SLC7A5
• SLCO1B1
• SLCO1B3
• TDO2
• TSHR
• GPR17
• DNMT1
• EHMT2
• CA3
• ALPI
• ALPL
• ARSA
• BAZ2B
• BLM
• CA1
• CA12
• CA14
• CA4
• ALB
• CA6
• CA7
• CA9

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• 5HT2A
• AHR
• CP2C9
• CP2CJ
• CP2D6
• GP139

Drug classes

• Antidepressive Agents
• Antidepressive Agents, Second-Generation
• Central Nervous System Agents
• Psychotropic Drugs

ATC classes

• N06A · ANTIDEPRESSANTS

Cross-references

• PubChem CID: 6305
• ChEMBL: CHEMBL54976
• DrugBank: DB00150
• ChEBI: CHEBI:57719
• KEGG: C00078
• RxNorm: 10898
• PDB: LTR
• Wikipedia: Tryptophan
• TTD: D05EJG
• LINCS BRD: BRD-K83776863

Synonyms

• L-Tryptophan
• tryptophane
• L-Tryptophane
• Tryptophane
• Triptofano
• L-tryptophan
• (-)-tryptophan
• Tryptophan ((-),l,s)
• Tryptophan, l-
• Trytophan-
• NSC-13119
• Gppe pdr sach
• Optimax
• Optimax wv
• Pacitron
• Ardeytropin
• Kalma
• LTR
• Lyphan
• Sedanoct
• Trofan
• Trp
• Tryptacin
• Tryptan
• Tryptophanum
• Triptofano [Spanish]
• Tryptophane [French]
• Tryptophanum [Latin]
• EH 121
• MT1
• T 0254
• Alti-Tryptophan
• L-TRYPTOPHAN SIGMA GRADE
• L-Trp
• L-Tryptofan
• L-Ttp
• TRP NH3+ COOH
• TRP-01

Reported adverse events

• Electrolyte imbalance
• Hypersensitivity
• Infection
• Pulmonary embolism
• Refeeding syndrome
• Alkalosis
• Extravasation
• Glycosuria
• Local reaction
• Metabolic acidosis
• Death
• Sepsis