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ADEFOVIR DIPIVOXIL
SynDRA canonical compound SYN0002573 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Mechanism of action | DNA polymerase inhibitor |
|---|
| Indication | hepatitis B |
|---|
| Disease area | infectious disease |
|---|
All known targets
- HBV RT
- HBcAg
- P
- POLG
- CYP3A4
- HSV UL30
Mechanisms of action (all sources)
- DNA polymerase inhibitor
- HBV RT MODULATOR
- P inhibitor
- cytochrome P450 activator
- HSV UL30 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NR1I2
- FAP
- POLA1
- DRD3
- DRD2
- ABCB11
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- KCNH2
- MAOA
- MC3R
- MLNR
- NPY1R
- NR3C1
- HRH3
- OPRD1
- OPRK1
- OPRM1
- PDE3A
- PDE4D
- PGR
- PTGS2
- SLC10A1
- SLC22A6
- SLC6A2
- SLC6A3
- SLC6A4
- HTR1A
- HRH1
- HRH2
- CCKAR
- ADORA2A
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- ADRB1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACES
- ATXN2
- CP3A4
- CP3A7
- GLI3
- IFNG
- KSYK
- NF2L2
- NSD2
- RARA
- SYK
- TP53
Drug classes
- Nucleoside Reverse Transcriptase Inhibitors
- Anti-Infective Agents
- Antiviral Agents
- Enzyme Inhibitors
- Nucleic Acid Synthesis Inhibitors
- Reverse Transcriptase Inhibitors
- Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor
- Anti-Retroviral Agents
ATC classes
- J05A · DIRECT ACTING ANTIVIRALS
Cross-references
Synonyms
- HEPSERA
- Hepsera
- hepsera
- preveon
- Adefovir pivoxil
- Adefovir di(pivaloyloxymethyl) ester
- GS-0840
- Adefovirdipivoxl
- Preveon
- YouHeDing
- Adefovir depivoxil
- GS 840;Piv2PMEA
- Adefovir dipivoxil (USAN)
- Adefovir pivoxil (JAN)
- Bis(pom)PMEA
- Bis-POM PMEA
- GS-840
- Hepsera (TM)
- Hepsera (TN)
- Preveon (TN)
- Bis(POM)-PMEA
- Bis-POM PMEA, Adefovir Dipivoxil
- Bis-POM PMEA, Preveon, Hepsera, Adefovir Dipivoxil
- Bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine
- 9-(2-((-Bis((pivaloyloxy)methoxy)phosphinyl)methoxy)ethyl)adenine
- 9-(2-((Bis((pivaloyloxy)methoxy)phosphinyl)methoxy)ethyl)adenine
- ADV
- adefovir.dipivoxil
- bis-POM PMEA
- GS 0840
- Adefovir dipivoxil [USAN]
- Adefovir Dipivoxil (Preveon, Hepsera)
- U6Q8Z01514
- NCGC00164624-01
- ADEFOVIR PIVOXIL [JAN]
- 9-[2-[Bis(pivaloyloxymethoxy)phosphorylmethoxy]ethyl]adenine
Reported adverse events
- Lactic acidosis
- HIV infection
- Lactic acid
- Fanconi syndrome
- Headache
- Asthenia
- Dyspepsia
- Flatulence
- Hepatitis
- Nausea
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