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TIROFIBAN
SynDRA canonical compound SYN0002557 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ITGB3 |
|---|
| Mechanism of action | Structural glycoprotein antagonist |
|---|
| Indication | myocardial infarction | refactory angina |
|---|
| Disease area | cardiology |
|---|
All known targets
Mechanisms of action (all sources)
- Platelet aggregation inhibitor
- Structural glycoprotein antagonist
- ITGB3 INHIBITOR
- Integrin alpha-IIb/beta-3 inhibitor
- ITGA2B INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- SLC6A4
- ACHE
- HTR1A
- SLC6A3
- SLC6A2
- PTGS1
- PGR
- PDE4A
- PDE3A
- OPRM1
- MAOA
- KCNH2
- HTR2B
- HRH3
- ADORA1
- HDAC6
- F2
- F10
- ESR1
- DRD3
- DRD1
- CHRM2
- CHRM1
- AR
- ADRA2A
- ADRA1A
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Platelet Aggregation Inhibitor
- Cardiovascular Agents
- Fibrinolytic Agents
- Hematologic Agents
- Platelet Aggregation Inhibitors
ATC classes
- B01A · ANTITHROMBOTIC AGENTS
Cross-references
Synonyms
- AGGRASTAT
- Aggrastat
- TIROFIBAN HYDROCHLORIDE
- aggrestat
- tirofiban hydrochloride
- tirofiban HCl
- tirofiban hydrochloride monohydrate
- L-700,462
- aggrastat
- Agrastat
- AGG
- Tirofibanum
- Aggrastat (TN)
- Agrastat (TN)
- L-700462
- MK-383
- Tirofiban (INN)
- Tirofiban[BAN:INN]
- Tirofiban [INN:BAN]
- N-(BUTYLSULFONYL)-O-[4-(4-PIPERIDINYL)BUTYL]-L-TYROSINE
- N-(Butylsulfonyl)-O-(4-(4-piperidyl)butyl)-L-tyrosine
- N-(butylsulfonyl)-O-(4-piperidin-4-ylbutyl)-L-tyrosine
- N-(butylsulfonyl)-o-[4-(piperidin-4-yl)butyl]-l-tyrosine
- GGX234SI5H
- tirofibanum
- MK 383
- CHEBI:9605
- l-700462
- RefChem:57052
- DTXCID7085221
- B01AC17
- L700,462
- MFCD05237246
- L-Tyrosine, N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-
- TIROFIBAN [INN]
- C22H36N2O5S
- L-Tyrosine, N-(butylsulfonyl)-O-(4-(4-piperidinyl)butyl)-
- HSDB 7323
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